Data on the effects of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds on intraocular pressure of ocular normotensive rats
| Autor: | Pavel M. Vassiliev, Alexander A. Spasov, Adrian Julian Marcus, V. A. Anisimova, O. N. Zhukovskaya, Igor Nikolayevich Iezhitsa, Renu Agarwal, Nafeeza Mohd Ismail |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Ocular normotensive rats
Intraocular pressure Benzimidazole genetic structures Intraocular pressure lowering activity Pharmacology lcsh:Computer applications to medicine. Medical informatics 01 natural sciences chemistry.chemical_compound Imidazo[1 2-a]benzimidazoles Area under curve Pyrimido[1 2-a]benzimidazoles lcsh:Science (General) Rebound tonometry Multidisciplinary 010405 organic chemistry REBOUND TONOMETRY Pharmacology Toxicology and Pharmaceutical Science eye diseases 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Drug screening Time course lcsh:R858-859.7 sense organs lcsh:Q1-390 |
| Zdroj: | Data in Brief, Vol 18, Iss, Pp 523-554 (2018) Data in Brief |
| ISSN: | 2352-3409 |
| Popis: | This data is to document the intraocular pressure (IOP) lowering activity of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds in ocular normotensive rats. Effects of single drop application of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds on IOP in ocular normotensive rats are presented at 3 different concentrations (0.1%, 0.2% and 0.4%). Time course of changes in IOP is presented over 6 h period post-instillation. The IOP lowering activities of test compounds were determined by assessing maximum decrease in IOP from baseline and corresponding control, duration of IOP lowering and area under curve (AUC) of time versus response curve. Data shown here may serve as benchmarks for other researchers studying IOP-lowering effect of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds and would be useful in determining therapeutic potential of these test compounds as IOP lowering agents. Keywords: Drug screening, Intraocular pressure, Intraocular pressure lowering activity, Imidazo[1,2-a]benzimidazoles, Pyrimido[1,2-a]benzimidazoles, Ocular normotensive rats, Rebound tonometry |
| Databáze: | OpenAIRE |
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