Clarithromycin Stops Lung Function Decline in Airway-Centered Interstitial Fibrosis
| Autor: | S Caulet-Maugendre, B Desrues, Mallorie Kerjouan, S Guillot, Stéphane Jouneau, C Meunier, P Delaval |
|---|---|
| Přispěvatelé: | Le Corre, Morgane, Service de pneumologie [Rennes] = Pneumology [Rennes], CHU Pontchaillou [Rennes], Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes], Service des explorations fonctionnelles [CHU Rennes], Service de radiologie et imagerie médicale [Rennes] = Radiology [Rennes], Service des explorations fonctionnelles respiratoires, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes] |
| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology MESH: Treatment Failure Pulmonary Fibrosis medicine.medical_treatment MESH: Respiratory Function Tests [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract Gastroenterology 0302 clinical medicine Fibrosis Clarithromycin Pulmonary fibrosis Treatment Failure Enzyme Inhibitors Interstitial lung disease Esomeprazole respiratory system Anti-Bacterial Agents Respiratory Function Tests 3. Good health medicine.anatomical_structure MESH: Enzyme Inhibitors 030220 oncology & carcinogenesis medicine.drug Adult Pulmonary and Respiratory Medicine medicine.medical_specialty Prednisolone Lung biopsy 03 medical and health sciences MESH: Anti-Bacterial Agents Internal medicine medicine Humans MESH: Clarithromycin Lung transplantation Glucocorticoids MESH: Humans Lung MESH: Pulmonary Fibrosis business.industry MESH: Esomeprazole Sodium MESH: Adult medicine.disease MESH: Male Radiography 030228 respiratory system [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract Lung Diseases Interstitial MESH: Glucocorticoids MESH: Prednisolone Airway business MESH: Lung Diseases Interstitial |
| Zdroj: | Respiration Respiration, Karger, 2013, 85 (2), pp.156-9. ⟨10.1159/000341982⟩ |
| ISSN: | 1423-0356 0025-7931 |
| DOI: | 10.1159/000341982 |
| Popis: | International audience; Airway-centered interstitial fibrosis (ACIF) is a distinct type of lung interstitial fibrosis characterized by lesions centered on the airways. Several cases reported in the literature showed little to no effect of corticosteroids and a high mortality rate in the absence of lung transplantation. No other efficient approach is described for the treatment of this type of fibrosis. We report for the first time the case of a 44-year-old patient diagnosed with ACIF on surgical lung biopsy and stabilized with clarithromycin after failure of systemic corticosteroids. We need to confirm this benefit in other patients to ascertain the anti-inflammatory effect of macrolides, which are far less harmful compared to corticosteroids or immunosuppressant drugs. |
| Databáze: | OpenAIRE |
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