Eradication of hepatitis C virus is associated with the attenuation of steatosis as evaluated using a controlled attenuation parameter
| Autor: | Kazuhiko Koike, Tamaki Kobayashi, Momoe Endo, Mamiko Sato, Hitoshi Ikeda, Tomomi Iwai, Hiroaki Gotoh, Kohei Shimizu, Ryosuke Tateishi, Yoko Soroida, Hiromi Hikita, Yutaka Yatomi, Masaya Sato |
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| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Hepatitis C virus Hepacivirus lcsh:Medicine medicine.disease_cause Gastroenterology Antiviral Agents Severity of Illness Index Virus Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Medicine Humans lcsh:Science Aged Multidisciplinary biology business.industry Cholesterol lcsh:R Fatty liver Cholesterol HDL Hepatitis C Cholesterol LDL Hepatitis C Chronic Middle Aged medicine.disease biology.organism_classification Discontinuation Fatty Liver chemistry Liver 030220 oncology & carcinogenesis Elasticity Imaging Techniques RNA Viral lcsh:Q 030211 gastroenterology & hepatology Female Steatosis business |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-6 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Chronic hepatitis C virus (HCV) infection was shown to cause hepatic steatosis or suppression of serum lipid levels. However, little is known about the changes in hepatic steatosis following HCV eradication. We aimed to evaluate this issue using the controlled attenuation parameter (CAP), which was recently shown to provide a standardized non-invasive measure of hepatic steatosis. We enrolled 70 patients with chronic HCV infections and steatosis (CAP of over 248 dB/m) who had achieved a sustained viral response at 12 weeks after discontinuation of antiviral treatment using direct-acting antivirals (DAA). We then evaluated the state of hepatic steatosis before and after HCV eradication. We also investigated the changes in serum parameters such as cholesterol and glucose levels. The median value of CAP level decreased significantly after HCV eradication from 273 dB/m to 265 dB/m (P = 0.034). Also, LDL and HDL cholesterol levels increased significantly after HCV eradication (P = 0.002 and P = 0.027, respectively). In conclusion, a decrease in hepatic steatosis after HCV eradication with DAA was revealed in chronic hepatitis C patients with significant steatosis. Cancellation of the viral effect is a possible underlying cause of hepatic steatosis improvement and increase in HDL and LDL cholesterol levels. |
| Databáze: | OpenAIRE |
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