Behavioral effects of the cyclic cholecystokinin peptide analogue JMV-320
| Autor: | V.V. Petkov, Ch.I. Hadjiivanova, Jean Martinez, R. Kehayov, Muriel Amblard |
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| Rok vydání: | 1995 |
| Předmět: |
Agonist
Male medicine.medical_specialty Time Factors Physiology medicine.drug_class Avoidance response Biochemistry Open field Sincalide Tetragastrin Cellular and Molecular Neuroscience Endocrinology Hormone Antagonists Punishment In vivo Memory Internal medicine medicine Avoidance Learning Animals Rats Wistar Receptor Maze Learning Cholecystokinin Analysis of Variance Dose-Response Relationship Drug digestive oral and skin physiology Ligand (biochemistry) Rats Dose–response relationship Exploratory Behavior Receptors Cholecystokinin Reinforcement Psychology hormones hormone substitutes and hormone antagonists |
| Zdroj: | Peptides. 16(5) |
| ISSN: | 0196-9781 |
| Popis: | The in vivo effects of JMV-320 (a highly selective CCKB receptor ligand) and of CCK-4 on exploratory activity and memory in rats were compared. JMV-320 and CCK-4 did not modulate exploratory activity in an open field test but decreased it in an elevated plus-maze. CCK-4 (50 micrograms/kg) impaired passive avoidance response 3 h after training and JMV-320 (1 and 10 micrograms/kg) decreased active avoidance response 24 h after training. The behavioral effects of JMV-320 resemble the effects of CCK-4 and suggest that in vivo JMV-320 acts as a CCKB receptor agonist. |
| Databáze: | OpenAIRE |
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