Effect of Dietary Sugar Intake on Biomarkers of Subclinical Inflammation: A Systematic Review and Meta-Analysis of Intervention Studies
| Autor: | Lukas Schwingshackl, Katharina J Penczynski, Karen W. Della Corte, Ines Perrar, Christian Herder, Anette E. Buyken |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Sucrose food.ingredient Databases Factual Dietary Sugars Physiology 030209 endocrinology & metabolism Fructose Review high fructose corn syrup 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine food Humans Medicine Randomized Controlled Trials as Topic dietary sucrose Inflammation 030109 nutrition & dietetics Nutrition and Dietetics Adiponectin High-fructose corn syrup business.industry Dietary Sucrose inflammatory markers dietary glucose Diet Corn syrup Observational Studies as Topic C-Reactive Protein Systematic review chemistry dietary fructose Meta-analysis Cytokines E-Selectin business Biomarkers Food Science |
| Zdroj: | Nutrients |
| ISSN: | 2072-6643 |
| Popis: | It has been postulated that dietary sugar consumption contributes to increased inflammatory processes in humans, and that this may be specific to fructose (alone, in sucrose or in high-fructose corn syrup (HFCS)). Therefore, we conducted a meta-analysis and systematic literature review to evaluate the relevance of fructose, sucrose, HFCS, and glucose consumption for systemic levels of biomarkers of subclinical inflammation. MEDLINE, EMBASE, and Cochrane libraries were searched for controlled intervention studies that report the effects of dietary sugar intake on (hs)CRP, IL-6, IL-18, IL-1RA, TNF-α, MCP-1, sICAM-1, sE-selectin, or adiponectin. Included studies were conducted on adults or adolescents with ≥20 participants and ≥2 weeks duration. Thirteen studies investigating 1141 participants were included in the meta-analysis. Sufficient studies (≥3) to pool were only available for (hs)CRP. Using a random effects model, pooled effects of the interventions (investigated as mean difference (MD)) revealed no differences in (hs)CRP between fructose intervention and glucose control groups (MD: −0.03 mg/L (95% CI: −0.52, 0.46), I2 = 44%). Similarly, no differences were observed between HFCS and sucrose interventions (MD: 0.21 mg/L (−0.11, 0.53), I2 = 0%). The quality of evidence was evaluated using Nutrigrade, and was rated low for these two comparisons. The limited evidence available to date does not support the hypothesis that dietary fructose, as found alone or in HFCS, contributes more to subclinical inflammation than other dietary sugars. |
| Databáze: | OpenAIRE |
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