Aging influence on pulmonary and systemic inflammation and neural metabolomics arising from pulmonary multi-walled carbon nanotube exposure in apolipoprotein E-deficient and C57BL/6 female mice
| Autor: | Tamara L. Young, David Scieszka, Jessica G. Begay, Selita N. Lucas, Guy Herbert, Katherine Zychowski, Russell Hunter, Raul Salazar, Andrew K. Ottens, Aaron Erdely, Haiwei Gu, Matthew J. Campen |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Inhalation Toxicology. 35:86-100 |
| ISSN: | 1091-7691 0895-8378 |
| DOI: | 10.1080/08958378.2022.2026538 |
| Popis: | Environmental exposures exacerbate age-related pathologies, such as cardiovascular and neurodegenerative diseases. Nanoparticulates, and specifically carbon nanomaterials, are a fast-growing contributor to the category of inhalable pollutants, whose risks to health are only now being unraveled. The current study assessed the exacerbating effect of age on multiwalled-carbon nanotube (MWCNT) exposure in young and old C57BL/6 and ApoEFemale C57BL/6 and apolipoprotein E-deficient (ApoEPulmonary neutrophil infiltration was induced by MWCNT in bronchoalveolar lavage fluid in both C57BL/6 and ApoEAge influences the pulmonary and neurological responses to short-term MWCNT exposure. However, with only the model of moderate aging (15 months) in this study, the responses appeared modest compared to inhaled toxicant impacts in more advanced aging models. |
| Databáze: | OpenAIRE |
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