Overexpression of HURP mRNA in head and neck carcinoma and association with in�vitro response to vinorelbine
| Autor: | Ahmed S. Al-Khafaji, Janet M. Risk, Richard Shaw, Andrew Schache, Amelia Acha-Sagredo, Triantafillos Liloglou, Paschalia Pantazi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Oncogene Cancer Biology Cell cycle medicine.disease_cause Vinorelbine medicine.disease Molecular medicine Head and neck squamous-cell carcinoma 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Cancer research medicine Carcinogenesis Lung cancer medicine.drug |
| Zdroj: | ONCOLOGY LETTERS |
| ISSN: | 1792-1082 1792-1074 |
| DOI: | 10.3892/ol.2020.11339 |
| Popis: | HURP gene encodes the hepatoma upregulated protein (HURP), a microtubule associated protein regulating mitotic spindle dynamics, which promotes chromosomal congression and alignment during mitosis, with a potential role in tumorigenesis. In the present study, HURP mRNA expression was investigated by reverse transcription-quantitative PCR in oropharyngeal squamous cell carcinoma (OPSCC). Primary OPSCC tumors from 107 patients and 48 adjacent normal tissues, as well as 12 respiratory tract cancer cell lines (9 head and neck squamous cell carcinoma, 2 lung cancer and 1 normal bronchial) were utilised in the present study. mRNA expression levels of HURP were higher in malignant OPSCC tissues compared with in normal mucosa (P |
| Databáze: | OpenAIRE |
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