Association between Virus-Specific Cytotoxic T-Lymphocyte and Helper Responses in Human Immunodeficiency Virus Type 1 Infection
| Autor: | Spyros A. Kalams, Eric S. Rosenberg, Alicja Trocha, D. S. Colbert, Norman G. Jones, Bruce D. Walker, Amy K. Shea, Susan Buchbinder, James M. Billingsley |
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| Rok vydání: | 1999 |
| Předmět: |
viruses
Immunology HIV Core Protein p24 Human immunodeficiency virus (HIV) Gene Products gag HIV Infections Biology medicine.disease_cause Microbiology Virus Cohort Studies Immune system Virology medicine Humans Cytotoxic T cell Viremia Cd4 cell count RNA T-Lymphocytes Helper-Inducer CTL Insect Science Chronic Disease HIV-1 Pathogenesis and Immunity Viral load Cell Division T-Lymphocytes Cytotoxic |
| Zdroj: | Journal of Virology. 73:6715-6720 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.73.8.6715-6720.1999 |
| Popis: | Cellular immune responses are thought to be an important antiviral host defense, but the relationship between virus-specific T-helper and cytotoxic-T-lymphocyte (CTL) responses has not been defined. To investigate a potential link between these responses, we examined functional human immunodeficiency virus type 1 (HIV-1)-specific memory CTL precursor frequencies and p24-specific proliferative responses in a cohort of infected untreated persons with a wide range of viral loads and CD4 cell counts. Levels of p24-specific proliferative responses positively correlated with levels of Gag-specific CTL precursors and negatively correlated with levels of plasma HIV-1 RNA. These data linking the levels of HIV-specific CTL with virus-specific helper cell function during chronic viral infection provide cellular immunologic parameters to guide therapeutic and prophylactic vaccine development. |
| Databáze: | OpenAIRE |
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