Predicting mortality in bronchiectasis using bronchiectasis severity index and FACED scores: a 19-year cohort study
| Autor: | Steven Cowman, Michele Fernandes, Huw Ellis, Robert Wilson, Michael R. Loebinger |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Pediatrics medicine.medical_specialty Kaplan-Meier Estimate Severity of Illness Index Body Mass Index Cohort Studies 03 medical and health sciences 0302 clinical medicine Forced Expiratory Volume Severity of illness Humans Medicine Longitudinal Studies 030212 general & internal medicine Aged Proportional Hazards Models Retrospective Studies Bronchiectasis Receiver operating characteristic business.industry Proportional hazards model Retrospective cohort study Middle Aged Prognosis medicine.disease Haemophilus influenzae Streptococcus pneumoniae ROC Curve 030228 respiratory system Carrier State Pseudomonas aeruginosa Disease Progression Predictive power Physical therapy Female Tomography X-Ray Computed business Body mass index Cohort study |
| Zdroj: | European Respiratory Journal. 47:482-489 |
| ISSN: | 1399-3003 0903-1936 |
| Popis: | The clinical course of bronchiectasis is unpredictable, posing a challenge both in clinical practice and in research. Two mortality prediction scores, the bronchiectasis severity index (BSI) and FACED scores, have recently been developed. The aim of this study was to assess the ability of these scores to predict long-term mortality and to compare the two scores.The study was a single-centre retrospective cohort analysis consisting of 91 subjects originally recruited in 1994. BSI and FACED scores were calculated at the time of enrolment and long-term mortality ascertained. Data was available for 74 patients with a median of 18.8 years of follow-up.Both scoring systems had similar predictive power for 5-year mortality (area under receiver operator characteristic curve (AUC) 0.79 for BSI and 0.8 for FACED). Both scores were able to predict 15-year mortality with the FACED score showing slightly superior predictive power (AUC 0.82 versus 0.69, p=0.0495).This study provides further validation of the FACED and BSI scores for the prediction of mortality in bronchiectasis and demonstrates their utility over a longer period than originally described. Whilst both scores had excellent predictive power, the FACED score was superior for 15-year mortality. |
| Databáze: | OpenAIRE |
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