Sentinel lymph node biopsy in breast cancer: review on various methodological approaches
| Autor: | Baha Zengel, Ulkem Yararbas, Ahmet Sirinocak, Guliz Ozkok, Ali Galip Denecli, Hakan Postaci, Adam Uslu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research Injections Intradermal Contrast Media Breast Neoplasms Sulfides 030218 nuclear medicine & medical imaging Breast Neoplasms Male 03 medical and health sciences 0302 clinical medicine Chlorides Rosaniline Dyes Frozen Sections Humans Colloids Coloring Agents Technetium Tc 99m Aggregated Albumin Aged Retrospective Studies Aged 80 and over Chi-Square Distribution Sentinel Lymph Node Biopsy General Medicine Middle Aged Rhenium Oncology 030220 oncology & carcinogenesis Lymphatic Metastasis Axilla Lymph Node Excision Female Lymph Nodes Radiopharmaceuticals |
| Zdroj: | Tumori. 99(2) |
| ISSN: | 2038-2529 |
| Popis: | Aims and background Sentinel lymph node biopsy has been accepted as a standard procedure for early stage breast cancer. In this retrospective analysis, the results obtained with different methodological approaches using radiocolloid with or without blue dye were examined. Methods A total of 158 sentinel lymph node biopsies were performed in 152 patients. Group A (85 patients) underwent lymphatic mapping using a combination of periareolar intradermal radiocolloid and subareolar blue dye injections. Group B (73 patients) underwent only periareolar intradermal radiocolloid injection. One large tin colloid and two small radiocolloids (nanocolloid of serum albumin -NC- and colloidal rhenium sulphide -CS-) were used. Results Successful lymphatic mapping was attained in 157 of 158 procedures (99.4%). Radiocolloids localized sentinel lymph nodes in 99.4% and blue dye in 75.3% of the cases. The number of sentinel lymph nodes removed was greater in nanocolloid and colloidal rhenium sulphide groups ( P ≤0.05). Among 60 metastatic sentinel lymph nodes, frozen section analysis using hematoxylin and eosin staining failed to detect 1 macro- and 10 micrometastasis. Radiocolloid uptake was higher in sentinel lymph nodes accumulating blue dye (1643 ± 3216 counts/10 sec vs 526 ± 1284 counts/10 sec, P Conclusions Radiocolloids were more successful than blue dye in sentinel lymph node detection. More sentinel lymph nodes were harvested with small colloids, but different sized radiocolloids were similarly successful. Sentinel lymph nodes having higher radiocolloid uptake tended to accumulate blue dye more frequently. Sentinel lymph nodes manifested higher count rates when a larger colloid was used. Frozen section was very successful in detecting macrometastatic disease in sentinel lymph nodes, but the technique failed in most of the micrometastates. |
| Databáze: | OpenAIRE |
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