Probiotic Prato cheese consumption attenuates development of renal calculi in animal model of urolithiasis
| Autor: | Anderson S. Sant'Ana, Erick Almeida Esmerino, Adriano G. Cruz, Márcio Eduardo de Barros, Marcia C. Silva, Elson Rogério Tavares Filho, Aline A. Martins, Leonardo Emanuel de Oliveira Costa, Pablo Christiano Barboza Lollo, Renata S.L. Raices, Valfredo de Almeida Santos-Junior, Mônica Q. Freitas, Marcus Vinicius S. Ferreira, Juliana S. Graça, Hugo L.A. Silva |
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| Rok vydání: | 2018 |
| Předmět: |
Prato cheese
0301 basic medicine Lactobacillus casei Sodium Calcium oxalate Medicine (miscellaneous) chemistry.chemical_element Calcium Probiotic Excretion 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Urolithiasis medicine TX341-641 Food science Creatinine 030109 nutrition & dietetics Nutrition and Dietetics biology Nutrition. Foods and food supply 04 agricultural and veterinary sciences medicine.disease biology.organism_classification 040401 food science chemistry Urea Kidney stones Food Science |
| Zdroj: | Journal of Functional Foods, Vol 49, Iss, Pp 378-383 (2018) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2018.08.041 |
| Popis: | The effect of probiotic Prato cheese containing Lactobacillus casei 01 (7–8 log CFU/g) on urolithiasis was evaluated. Twenty-four male Rattus novergicus, Wistar line (8 weeks old), with surgical implant of calcium oxalate tablets (CaOx) were used. The animals were organized into four groups (n = 6) randomly divided into: Naive Control (NC); Control of calcium oxalate (CaOx-C); Calcium oxalate with conventional cheese (CC), Calcium oxalate with probiotic cheese (PC). Urinalysis was performed to evaluate volume, density, pH, urea, creatinine, together with serum urea, creatinine, sodium, potassium and magnesium, and latero-lateral radiographs of the abdominal cavity. Only the PC group presented a significant reduction in the size of the pellets (CaOx-C Δ = 1.24 mg, CC Δ = 5.78 mg and e PC Δ = −0.933 mg). Changes in urinary mineral excretion were observed, with a reduction in potassium (NC = 183.7, Caox-C = 313.8, CC = 108, and e PC = 76.4 mmol/L), calcium (NC = 11.0, Caox-C = 3.8, CC = 4.7 and e PC = 3.4 mg/dL. p = 0.002) and magnesium (NC = 11.4, Caox-C = 12.9, CC = 5.7 e PC = 2.4 mg/dL, p = 0.01) excretion. Radiological examination confirmed the role of PC in preventing kidney stone development, which support the PC a superior to the current therapeutics, together with a functional ingredient in nutraceutical applications. |
| Databáze: | OpenAIRE |
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