Asymmetric dimethylarginine enhances cardiovascular risk prediction in patients with chronic heart failure
| Autor: | Christina Dückelmann, Dominik G. Haider, Friedrich Mittermayer, Jörg Eichinger, Michael Wolzt, Johann Altenberger |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Heart disease medicine.drug_class Arginine Risk Assessment Disease-Free Survival chemistry.chemical_compound Ventricular Dysfunction Left Interquartile range Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans Prospective Studies Risk factor Aged Heart Failure business.industry Hazard ratio medicine.disease Prognosis Peptide Fragments Endocrinology chemistry Heart failure Austria Cohort Cardiology Female Cardiology and Cardiovascular Medicine Asymmetric dimethylarginine business Biomarkers |
| Zdroj: | Arteriosclerosis, thrombosis, and vascular biology. 27(9) |
| ISSN: | 1524-4636 |
| Popis: | Objective— The purpose of this study was to investigate whether elevated asymmetrical dimethylorginine (ADMA) concentrations are associated with increased cardiovascular risk in chronic heart failure (HF) patients. Methods and Results— 253 patients with symptomatic chronic HF and impaired left ventricular function (median age 70 years, 202 males) were followed for a median of 14.2 months (interquartile range 6.8 to 21.2). ADMA and N-terminal pro-brain natriuretic peptide (NT-proBNP) were assessed by high performance liquid chromatography and by an enzyme-linked immunosorbent assay, respectively. Subjects with ADMA concentrations in the highest tertile had a significantly higher adjusted hazard ratio (HR; 2.00; 95% confidence interval [CI] 1.01 to 3.97) for occurrence of an end point (cardiac decompensation, major adverse cardiovascular events or all-cause mortality) compared with patients in the lowest tertile ( P =0.046) during the first 6 months of follow-up. NT-proBNP also identified subjects at risk before adjustment for confounders at 6 and 12 months of follow-up. HR for patients with ADMA and NT-proBNP in the highest tertile was significantly increased (3.68, CI 1.67 to 8.14; at 6 months follow-up) compared with patients without ADMA and NT-proBNP in the highest tertile ( P Conclusions— Elevated ADMA plasma concentrations are associated with adverse cardiovascular outcome in patients with chronic HF. Quantification of ADMA with NT-proBNP improves risk stratification in this cohort. |
| Databáze: | OpenAIRE |
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