Diagnostic Performance of the Fujifilm SILVAMP TB-LAM in Children with Presumptive Tuberculosis

Autor:	Lydia Canales-Aliaga, Jacqueline Gautier, José Domínguez, Luis E. Cuevas, Tomàs M. Pérez-Porcuna, Mariette Jean Coute Doresca, Raquel Villar-Hernández, Jacob Creswell, Beatriz Sallés-Mingels, Margareth Narcisse, Patricia Comella-del-Barrio, Barbara Molina-Moya
Rok vydání:	2021
Předmět:	medicine.medical_specialty Tuberculosis diagnosis Human immunodeficiency virus (HIV) Signs and symptoms medicine.disease_cause Article Sputum testing Smear microscopy 03 medical and health sciences 0302 clinical medicine children Internal medicine medicine 030212 general & internal medicine Respiratory samples 0303 health sciences Lipoarabinomannan 030306 microbiology business.industry General Medicine LAM medicine.disease urine 3. Good health tuberculosis point-of-care Biomarker (medicine) Medicine wf_220 ws_280 lipoarabinomannan wf_200 business
Zdroj:	Journal of Clinical Medicine r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname Volume 10 Issue 9 Journal of Clinical Medicine, Vol 10, Iss 1914, p 1914 (2021)
ISSN:	2077-0383
DOI:	10.3390/jcm10091914
Popis:	Current diagnostics for tuberculosis (TB) only manage to confirm a small proportion of children with TB and require respiratory samples, which are difficult to obtain. There is a need for non-invasive biomarker-based tests as an alternative to sputum testing. Fujifilm SILVAMP TB lipoarabinomannan (FujiLAM), a lateral-flow test to detect lipoarabinomannan in urine, is a novel non-sputum-based point-of-care diagnostic reported to have increased sensitivity for the diagnosis of TB among human immunodeficiency virus (HIV)-infected adults. We evaluate the performance of FujiLAM in children with presumptive TB. Fifty-nine children attending a paediatric hospital in Haiti with compatible signs and symptoms of TB were examined using Xpert MTB/RIF, smear microscopy and X-rays, and classified according to the certainty of diagnosis into bacteriologically confirmed TB (n = 5), unconfirmed TB (bacteriologically negative, n = 50) and unlikely TB (n = 4). Healthy children (n = 20) were enrolled as controls. FujiLAM sensitivity and specificity were 60% and 95% among children with confirmed TB. FujiLAM’s high specificity and its characteristics as a point-of-care indicate the test has a good potential for the diagnosis of TB in children.
Databáze:	OpenAIRE
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