Indoloditerpenes from an algicolous isolate of Aspergillus oryzae
| Autor: | Qing Mei Zhu, Ming Feng Qiao, Qin Zhao Xue, Xiang-Hong Liu, Ke Li, Nai-Yun Ji |
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| Rok vydání: | 2010 |
| Předmět: |
Insecticides
Indoles Aspergillus oryzae Clinical Biochemistry Molecular Conformation Pharmaceutical Science Brine shrimp medicine.disease_cause Biochemistry Microbiology chemistry.chemical_compound Anti-Infective Agents Drug Discovery medicine Animals Molecular Biology Escherichia coli biology Chemistry Organic Chemistry Brain Fungi imperfecti biology.organism_classification Antimicrobial Terpenoid Rhodophyta Acetylcholinesterase Molecular Medicine Diterpene Artemia salina Artemia Diterpenes |
| Zdroj: | Bioorganicmedicinal chemistry letters. 20(19) |
| ISSN: | 1464-3405 |
| Popis: | Two new indoloditerpene derivatives asporyzin A (1) and asporyzin B (2), one new indoloditerpene asporyzin C (3), and three known related indoloditerpenes JBIR-03 (4), emindole SB (5), and emeniveol (6) were isolated from an endophytic fungus Aspergillus oryzae, isolated from the marine red alga Heterosiphonia japonica. Their structures were unambiguously established by spectroscopic techniques. In addition, all the isolates were evaluated preliminarily for insecticidal and antimicrobial activities in order to probe into their chemical defensive function. Compound 4 was more active against brine shrimp than the others, and 3 possessed potent activity against Escherichia coli. |
| Databáze: | OpenAIRE |
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