Dual Specificity Phosphatase 6 (DUSP6) Polymorphism Predicts Prognosis of Inoperable Non-Small Cell Lung Cancer after Chemoradiotherapy
| Autor: | Tian-Lu Wang, Lu Bai, Hai-Bo Zhang, Yang-Wu Ren, Ying-Qiu Song, Hong Yu, Bao-Sen Zhou, He-Tong Wang, Yuxia Zhao |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Lung Neoplasms ECOG Performance Status Single-nucleotide polymorphism Drug resistance Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Dual Specificity Phosphatase 6 Carcinoma Non-Small-Cell Lung Internal medicine Genotype medicine Humans Lung cancer Survival analysis Aged Proportional Hazards Models Aged 80 and over Proportional hazards model business.industry Chemoradiotherapy Middle Aged Prognosis medicine.disease 030104 developmental biology Cancer research Female business |
| Zdroj: | Clinical Laboratory. 62 |
| ISSN: | 1433-6510 |
| DOI: | 10.7754/clin.lab.2015.150432 |
| Popis: | BACKGROUND Dual-specificity phosphatase 6 (DUSP6) inactivates different target kinases to regulate cell proliferation and differentiation. Altered DUSP6 expressions or gene polymorphisms are associated with human cancer development including non-small cell lung cancer (NSCLC). DNA topoisomerase II alpha (TOP2A) regulates chromosome condensation and chromatid separation, and altered TOP2A expressions are associated with drug resistance development. This study assessed DUSP6 and TOP2A single nucleotide polymorphisms (SNPs) associated with NSCLC patient survival. METHODS This study included 152 surgically resected NSCLC patients and 277 chemoradiotherapy treated inoperable cases. DNA samples from each patient were genotyped for DUSP6 and TOP2A SNPs. Kaplan-Meier survival analysis, log-rank test, and Cox proportional hazard model were used to evaluate the association between these variants and NSCLC overall survival. RESULTS DUSP6 rs2279574 A/A genotype was associated with significantly poor inoperable NSCLC patient overall survival (A/A vs. C/C, adjusted HR = 1.549, 95% CI = 1.019-2.355). Stratification analysis against clinical stage, histology, weight loss, and ECOG performance status revealed that the DUSP6 rs2279574 A/A variant homozygous genotype is associated with a decrease in survival of stage IV NSCLC patients compared to those with the C/C genotype (log-rank, p = 0.003). No association was found among histology, weight loss, and ECOG performance status. Moreover, there was no association of TOP2A SNPs between clinicopathological and survival data. CONCLUSIONS Data obtained from the current study demonstrated that functional DUSP6 rs2279574 polymorphism was able to predict inoperable NSCLC patient survival after chemoradiotherapy. |
| Databáze: | OpenAIRE |
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