Immunity to cytomegalovirus in women with unexplained recurrent spontaneous abortion
| Autor: | Peter M. Johnson, C.A. Hart, J.J. Radcliffe, W.J.A. Francis |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Cellular immunity Abortion Habitual Lymphocyte Immunology Congenital cytomegalovirus infection Cytomegalovirus Abortion In Vitro Techniques medicine.disease_cause Antibodies Viral Lymphocyte Activation Herpesviridae Immunity Pregnancy medicine Humans Pregnancy Complications Infectious Immunity Cellular biology business.industry virus diseases Obstetrics and Gynecology medicine.disease medicine.anatomical_structure Humoral immunity Cytomegalovirus Infections biology.protein Female Immunotherapy Antibody business |
| Zdroj: | American journal of reproductive immunology and microbiology : AJRIM. 12(4) |
| ISSN: | 8755-8920 |
| Popis: | Humoral and cellular immunity to cytomegalovirus (CMV) has been assessed in women suffering unexplained recurrent spontaneous abortions (RSA). A significantly lower prevalence of serum anti-CMV antibodies was observed for RSA women compared with either their male partners or age-matched female controls, unlike for serum antibodies to Herpes simplex virus. In addition, there was a markedly impaired lymphocyte proliferative response to CMV for CMV-sero-positive RSA women compared with CMV-seropositive controls. These results indicate that women with unexplained RSA have difficulty in responding to CMV, and are of significance when considering leukocyte transfusion immunotherapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text