ANG II-induced attenuation of duck salt gland secretion does not depend upon the release of adrenal catecholamines
| Autor: | Jeff Tong, David G. Butler, Wallace Lam |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Epinephrine Physiology medicine.drug_class Dopamine medicine.medical_treatment Blood Pressure Sodium Chloride Biochemistry Dexamethasone Salt Gland Norepinephrine Endocrinology Heart Rate Internal medicine Adrenal Glands medicine Animals Saline Ecology Evolution Behavior and Systematics Salt gland Chemistry Angiotensin II Adrenalectomy Sodium Nasal Lavage Fluid Ducks Blood pressure Mineralocorticoid Potassium Osmoregulation Animal Science and Zoology hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Journal of Comparative Physiology B. 176:35-43 |
| ISSN: | 1432-136X 0174-1578 |
| DOI: | 10.1007/s00360-005-0029-8 |
| Popis: | Pekin ducks (Anas platyrhynchos) were bilaterally adrenalectomized (ADX) using a two-stage procedure and given daily i.m. injections of 1 mg kg bw(-1) of dexamethasone (DEXA), a steroid lacking mineralocorticoid activity, and 0.9% saline drinking water ad libitum to counterbalance renal losses of salt and water. Mean arterial blood pressure (mmHg) fell from 161+/- 3.7 (intact controls) to 116 +/- 6.9 (bilateral ADX+DEXA), a decrease of 27%, but heart rates (HR) were unchanged. The nasal salt glands were fully active after ADX + DEXA. Rates of fluid secretion and electrolyte and osmolal concentrations were unchanged. Secretion stopped, then rebounded several minutes later if ADX + DEXA ducks were injected i.v. with 1 microg of [Asn(1),Val(5)]-angiotensin II (ANG II) kg bw(-1) which showed that attenuation was not adrenal catecholamine-dependent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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