Animal models of right heart failure
| Autor: | Diederik E. van der Feen, Asger Andersen, Jacob Gammelgaard Schultz, Stine Andersen, Georg Hansmann, Harm Jan Bogaard |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary embolism (PE)
0301 basic medicine medicine.medical_specialty PULMONARY ARTERIAL-HYPERTENSION RIGHT-VENTRICULAR FUNCTION 02 engineering and technology Review Article on Right Ventricular Dysfunction Pulmonary heart disease 03 medical and health sciences Mineralocorticoid receptor Right heart failure PLATELET THROMBOEMBOLIC RESPONSES RAT MODEL pulmonary heart disease SOLUBLE GUANYLATE-CYCLASE Medicine Risk factor Intensive care medicine Cause of death Pulmonary hypertension (PH) Pressure overload BLOOD-FLOW business.industry 021001 nanoscience & nanotechnology medicine.disease Pulmonary hypertension congenital heart defects animal models Animal models CANINE MODEL 030104 developmental biology Congenital heart defects INHALED NITRIC-OXIDE ACTIVATED-RECEPTOR-GAMMA Right heart PORCINE MODEL pulmonary embolism (PE) 0210 nano-technology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Andersen, A, van der Feen, D E, Andersen, S, Schultz, J G, Hansmann, G & Bogaard, H J 2020, ' Animal models of right heart failure ', Cardiovascular Diagnosis and Therapy, vol. 10, no. 5, pp. 1561-1579 . https://doi.org/10.21037/cdt-20-400, https://doi.org/10.21037/cdt-20-400 Cardiovasc Diagn Ther Andersen, A, van der Feen, D E, Andersen, S, Schultz, J G, Hansmann, G & Bogaard, H J 2020, ' Animal models of right heart failure ', Cardiovascular diagnosis and therapy, vol. 10, no. 5, pp. 1561-1579 . https://doi.org/10.21037/cdt-20-400 |
| DOI: | 10.21037/cdt-20-400 |
| Popis: | Right heart failure may be the ultimate cause of death in patients with acute or chronic pulmonary hypertension (PH). As PH is often secondary to other cardiovascular diseases, the treatment goal is to target the underlying disease. We do however know, that right heart failure is an independent risk factor, and therefore, treatments that improve right heart function may improve morbidity and mortality in patients with PH. There are no therapies that directly target and support the failing right heart and translation from therapies that improve left heart failure have been unsuccessful, with the exception of mineralocorticoid receptor antagonists. To understand the underlying pathophysiology of right heart failure and to aid in the development of new treatments we need solid animal models that mimic the pathophysiology of human disease. There are several available animal models of acute and chronic PH. They range from flow induced to pressure overload induced right heart failure and have been introduced in both small and large animals. When initiating new pre-clinical or basic research studies it is key to choose the right animal model to ensure successful translation to the clinical setting. Selecting the right animal model for the right study is hence important, but may be difficult due to the plethora of different models and local availability. In this review we provide an overview of the available animal models of acute and chronic right heart failure and discuss the strengths and limitations of the different models. |
| Databáze: | OpenAIRE |
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