Increase of CD8+ T-effector memory cells in peripheral blood of patients with relapsing–remitting multiple sclerosis compared to healthy controls
| Autor: | Jean-Pierre Malin, K.F. Haegele, C.A. Stueckle, E. Sindern |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male CD8 Antigens Immunology chemical and pharmacologic phenomena Inflammation C-C chemokine receptor type 7 CD8-Positive T-Lymphocytes Lymphocyte Activation Flow cytometry Multiple Sclerosis Relapsing-Remitting Immune system Cerebrospinal fluid T-Lymphocyte Subsets immune system diseases medicine Humans Immunology and Allergy medicine.diagnostic_test Effector business.industry Multiple sclerosis virus diseases hemic and immune systems Middle Aged Flow Cytometry medicine.disease Neurology Case-Control Studies Female Neurology (clinical) medicine.symptom business Immunologic Memory CD8 |
| Zdroj: | Journal of Neuroimmunology. 183:168-174 |
| ISSN: | 0165-5728 |
| Popis: | CCR7 and CD45RA expression on CD4+ and CD8+ T-cells in blood (PB) of 16 patients with multiple sclerosis (MS) and 16 healthy controls and cerebrospinal fluid (CSF) of 10 patients suffering from MS were analysed by flow cytometric measurements. T-cells were divided by their distinct homing potentials and effector-functions in three groups: naïve T-cells (CCR7+, CD45RA+), central memory T-cells (TCM) (CCR7+, CD45RA-) and effector memory T-cells (TEM) (CCR7-, CD45RA-). There was a significant increase of CD8+ TEM-cells in PB of MS patients compared to healthy controls, indicating systemic immune activation. Further we found a relative depletion of CD8+ TEM-cells in CSF of MS patients compared to matching blood samples, suggesting that these cells represent the effector arm of the immune response and infiltrate the brain tissue at the sites of inflammation. |
| Databáze: | OpenAIRE |
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