In Vivo Tissue-Specific Regulation of the Human Papillomavirus Type 18 Early Promoter by Estrogen, Progesterone, and Their Antagonists
| Autor: | Victoria Juarez, Prasert Auewarakul, Alejandro García-Carrancá, Nestor Morales-Peza, Angel Cid-Arregui |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Gene Expression Regulation
Viral medicine.medical_specialty medicine.drug_class cervical cancer Transgene receptor Ovariectomy Estrous Cycle Mice Transgenic Cervix Uteri Biology Epithelium Mice Viral Proteins Hormone Antagonists Pregnancy Internal medicine Virology Progesterone receptor medicine estrogen Animals Transgenes Promoter Regions Genetic Cervix Papillomaviridae Estrogen receptor beta Progesterone Mice Inbred C3H Estradiol oncogenic HPV beta-Galactosidase Mice Inbred C57BL Mifepristone Tamoxifen medicine.anatomical_structure Endocrinology Estrogen LCR Vagina Ovariectomized rat gene expression Female Estrogen receptor alpha hormones hormone substitutes and hormone antagonists medicine.drug RU486 |
| Zdroj: | Virology. 294(1):135-140 |
| ISSN: | 0042-6822 |
| DOI: | 10.1006/viro.2001.1287 |
| Popis: | Human papillomavirus type 18 is a causative agent of epithelial cancers in the uterine cervix. We show here that estrogen and progesterone activate β-galactosidase expression from the early promoter of this virus in the genital epithelia of transgenic mice. Ovariectomy caused suppression of transgene expression exclusively in vagina and cervix epithelia. β-Galactosidase expression could be restored in ovariectomized females by administration of estrogen, alone or in combination with progesterone. Further, rescue of transgene expression was inhibited by the estrogen antagonist tamoxifen and the anti-progesterone RU486, suggesting that this was a specific effect. |
| Databáze: | OpenAIRE |
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