Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts:A Harmonization Study in the Mechanisms of the Development of Allergy Project

Autor: Eva Hallner, Marta Benet, Mariona Pinart, Stefano Guerra, Jacopo Lenzi, Isabella Annesi-Maesano, Manolis Kogevinas, Lourdes Cirugeda, Richard Albang, Esben Eller, Karin C. Lødrup Carlsen, Jordi Sunyer, Maties Torrent, Davide Gori, Maria Pia Fantini, Beatrix Gerhard, Kai-Håkon Carlsen, Rosemary R. C. McEachan, Thomas Keil, Emily S. Petherick, Isabelle Momas, Marie Standl, Cynthia Hohmann, Dieter Maier, Alet H. Wijga, Inger Kull, John Wright, Daniela Porta, Josep M. Antó, Ulrike Gehring, Christina Tischer, Jean Bousquet, Nour Baïz, Judith Garcia-Aymerich, Eleonora Minina, Fanny Rancière, Carsten Bindslev-Jensen, Silvia Narduzzi
Přispěvatelé: Benet, Marta, Albang, Richard, Pinart, Mariona, Hohmann, Cynthia, Tischer, Christina G, Annesi-Maesano, Isabella, Baïz, Nour, Bindslev-Jensen, Carsten, Lødrup Carlsen, Karin C, Carlsen, Kai-Hakon, Cirugeda, Lourde, Eller, Esben, Fantini, Maria Pia, Gehring, Ulrike, Gerhard, Beatrix, Gori, Davide, Hallner, Eva, Kull, Inger, Lenzi, Jacopo, McEachan, Rosemary, Minina, Eleonora, Momas, Isabelle, Narduzzi, Silvia, Petherick, Emily S, Porta, Daniela, Rancière, Fanny, Standl, Marie, Torrent, Matie, Wijga, Alet H, Wright, John, Kogevinas, Manoli, Guerra, Stefano, Sunyer, Jordi, Keil, Thoma, Bousquet, Jean, Maier, Dieter, Anto, Josep M, Garcia-Aymerich, Judith, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), Biomax Informatics [Planegg], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM), Université Pierre et Marie Curie - Paris 6 (UPMC), University of Oslo (UiO), Oslo University Hospital [Oslo], Alma Mater Studiorum University of Bologna (UNIBO), Utrecht University [Utrecht], Karolinska Institutet [Stockholm], Stockholm County Council, Université Sorbonne Paris Cité (USPC), Epidémiologie Environnementale : Impact Sanitaire des Pollutions (EA 4064), Université Paris Descartes - Paris 5 (UPD5), Direction de l'Action Sociale de l'Enfance et de la Santé (DASES), Mairie de Paris, Loughborough University, National Institute for Public Health and the Environment [Bilthoven] (RIVM), University of Arizona, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Benet, M, Albang, R, Pinart, M, Hohmann, C, Tischer, C G, Annesi-Maesano, I, Baïz, N, Bindslev-Jensen, C, Lødrup Carlsen, K C, Carlsen, K-H, Cirugeda, L, Eller, E, Fantini, M P, Gehring, U, Gerhard, B, Gori, D, Hallner, E, Kull, I, Lenzi, J, McEachan, R, Minina, E, Momas, I, Narduzzi, S, Petherick, E S, Porta, D, Rancière, F, Standl, M, Torrent, M, Wijga, A H, Wright, J, Kogevinas, M, Guerra, S, Sunyer, J, Keil, T, Bousquet, J, Maier, D, Anto, J M & Garcia-Aymerich, J 2019, ' Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts : A Harmonization Study in the Mechanisms of the Development of Allergy Project ', American Journal of Epidemiology, vol. 188, no. 2, pp. 408–417 . https://doi.org/10.1093/aje/kwy242
Am. J. Epidemiol. 188, 408-417 (2019)
American Journal of Epidemiology
American Journal of Epidemiology, Oxford University Press (OUP), 2019, 188 (2), pp.408-417. ⟨10.1093/aje/kwy242⟩
ISSN: 0002-9262
1476-6256
DOI: 10.1093/aje/kwy242
Popis: International audience; The numbers of international collaborations among birth cohort studies designed to better understand asthma and allergies have increased in the last several years. However, differences in definitions and methods preclude direct pooling of original data on individual participants. As part of the Mechanisms of the Development of Allergy (MeDALL) Project, we harmonized data from 14 birth cohort studies (each with 3-20 follow-up periods) carried out in 9 European countries during 1990-1998 or 2003-2009. The harmonization process followed 6 steps: 1) organization of the harmonization panel; 2) identification of variables relevant to MeDALL objectives (candidate variables); 3) proposal of a definition for each candidate variable (reference definition); 4) assessment of the compatibility of each cohort variable with its reference definition (inferential equivalence) and classification of this inferential equivalence as complete, partial, or impossible; 5) convocation of a workshop to agree on the reference definitions and classifications of inferential equivalence; and 6) preparation and delivery of data through a knowledge management portal. We agreed on 137 reference definitions. The inferential equivalence of 3,551 cohort variables to their corresponding reference definitions was classified as complete, partial, and impossible for 70%, 15%, and 15% of the variables, respectively. A harmonized database was delivered to MeDALL investigators. In asthma and allergy birth cohorts, the harmonization of data for pooled analyses is feasible, and high inferential comparability may be achieved. The MeDALL harmonization approach can be used in other collaborative projects.
Databáze: OpenAIRE
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