The baseline glomerular filtration rate, predictive of six-year survival in sub-Saharan African patients on antiretroviral therapy for HIV: Cohort study
| Autor: | Greta Oliveira Bere, Priscille Edou, Jean-Rodolphe Mackanga, J. Ibaba, Nancy Doumingou, Clémence Alène, Émeline-Gracia Mouendou Mouloungui, U.D. Kombila, J. B. Boguikouma, Jean-Baptiste Moussavou Kombila, L. Missounga, Franck-Éric Ehoumba Odzaga, Patrick Nzouto, Patrice-Emery Itoudi Bignoumba, Bellyse Lacmou, Alexandrine Nsie |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent 030232 urology & nephrology Human immunodeficiency virus (HIV) Renal function HIV Infections urologic and male genital diseases medicine.disease_cause Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine Humans Medicine Baseline (configuration management) Africa South of the Sahara Retrospective Studies urogenital system business.industry Proportional hazards model Retrospective cohort study Middle Aged Prognosis Antiretroviral therapy female genital diseases and pregnancy complications Survival Rate Anti-Retroviral Agents Nephrology Etiology Female business Glomerular Filtration Rate Cohort study |
| Zdroj: | Néphrologie & Thérapeutique. 15:220-225 |
| ISSN: | 1769-7255 |
| DOI: | 10.1016/j.nephro.2019.02.009 |
| Popis: | Recently, serious morbidity events associated with initial glomerular filtration rate (GFR) have been described during HIV infection, but this is insufficiently investigated in sub-Saharan Africa very affected by HIV.To assess the impact of baseline GFR prevailing during the first semester of the HIV infection management on six-year survival in peoples taking antiretroviral therapy.Closed retrospective cohort study. The death was the expected outcome, the baseline GFR (mL/min/1.73mAccording to baseline GFR:60, 60-89 and≥90, the six-year survival was 81.6%; 95.8% and 96.4% (P=0.067 Breslow). Adjusted hazard ratio for baseline GFR60 and 60-89 (vs. ≥90) were respectively 5.4 (95%CI: 1.4-19.9; P=0.012) and 1.2 (95%CI: 0.3-4.0; P=0.754). The etiological fraction of deaths attributable to baseline GFR: GFR60: 81% (95%CI: 0.31-0.95), GFR=60-89: 18.0% (95%CI: -0.7-0.8). Prognostic concordance index=0.84 (95%CI: 0.59-0.95) for GFR60 and 0.55 (95%CI: 0.27-0.81) for GFR 60-89.The etiological fraction of death and prognostic concordance index associated to baseline GFR level increase significantly with decline of baseline GFR.Baseline GFR seems to predict the six-year survival in African sub-Saharan patients treated for HIV. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect