Pulmonary exposure to metallic nanomaterials during pregnancy irreversibly impairs lung development of the offspring

Autor: Murielle Salomé, Jérôme Rose, Audrey Ridoux, Bernhard Hesse, Delphine Vantelon, Jean-Claude Pairon, Shamila Vibhushan, Florence Canoui-Poitrine, Erwan Paineau, Emmanuel Paul, Bernard Angeletti, Sophie Lanone, Marie-Laure Franco-Montoya, Christophe Delacourt, Arnaud Tiendrebeogo, Jorge Boczkowski
Přispěvatelé: Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Laboratoire de Physique des Solides (LPS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), European Synchrotron Radiation Facility (ESRF), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Service de santé publique [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), IMRB - CEPIA/'Clinical Epidemiology And Ageing : Geriatrics, Primary Care and Public Health' [Créteil] (U955 Inserm - UPEC), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut Santé-Travail Paris-Est [Créteil], Université Paris-Est Créteil, Faculté de Médecine [Créteil] (UPEC-Médecine), ANR-11-LABX-0064,SERENADE,Vers une conception de nanomatériaux innovants, durables et sûrs(2011), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), Clinical Epidemiology and Ageing : Geriatrie Soins Primaires et Santé Publique (CEpiA), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Beaussier, Catherine, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Lanone, Sophie, Vers une conception de nanomatériaux innovants, durables et sûrs - - SERENADE2011 - ANR-11-LABX-0064 - LABX - VALID, INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE - - Amidex2011 - ANR-11-IDEX-0001 - IDEX - VALID
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Vascular Endothelial Growth Factor A
0301 basic medicine
Silver
Materials science
Amniotic fluid
Offspring
Organogenesis
Placenta
Biomedical Engineering
Metal Nanoparticles
[SDU.STU]Sciences of the Universe [physics]/Earth Sciences
02 engineering and technology
Toxicology
[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Andrology
Mice
03 medical and health sciences
Fetal Stage
medicine
Animals
Respiratory system
Lung
lung development
Titanium
Air Pollutants
Inhalation Exposure
Pregnancy
030111 toxicology
Cerium
respiratory system
021001 nanoscience & nanotechnology
medicine.disease
Fibroblast Growth Factors
Mice
Inbred C57BL
medicine.anatomical_structure
Maternal Exposure
Prenatal Exposure Delayed Effects
Immunology
[SDU.STU] Sciences of the Universe [physics]/Earth Sciences
[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Nanoparticles
Gestation
Female
pregnancy
0210 nano-technology
Zdroj: Nanotoxicology
Nanotoxicology, 2017, 11 (4), pp.484-495. ⟨10.1080/17435390.2017.1311381⟩
Nanotoxicology, Taylor & Francis, 2017, 11 (4), pp.484-495. ⟨10.1080/17435390.2017.1311381⟩
ISSN: 1743-5390
1743-5404
Popis: International audience; Due to the growing commercial applications of manufactured nanoparticles (NPs), toxicological studies on NPs, especially during the critical window of development, are of major importance. The aim of the study was to assess the impact of respiratory exposure to metallic and metal oxide NPs during pregnancy on lung development of the offspring and to determine the key parameters involved in lung alterations. Pregnant mice were exposed to weekly doses of 100 mu g (total dose 300 mu g) of titanium dioxide (TiO2), cerium oxide (CeO2), silver (Ag) NPs or saline solution by nonsurgical intratracheal instillation. The offspring lungs were analyzed at different stages of lung development: fetal stage (gestational day 17.5), pulmonary alveolarization (post-delivery day 14.5) and lung maturity (post-delivery day 49.5). Regardless of the type of NP, maternal exposure during gestation induced long-lasting impairment of lung development of the offspring. This effect was accompanied by: i) decreased placental efficiency together with the presence of NPs in placenta, ii) no increase of inflammatory mediators present in amniotic fluid, placenta or offspring lungs and iii) decreased pulmonary expression of vascular endothelial growth factor-alpha (VEGF-alpha) and matrix metalloproteinase 9 (MMP-9) at the fetal stage, and fibroblast growth factor-18 (FGF-18) at the alveolarization stage. Respiratory exposure to metallic NPs during pregnancy induces stereotyped impairment of lung development with a lasting effect in adult mice, independently of the chemical nature of the NP.
Databáze: OpenAIRE
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