Treatment of a Patient with a Nodal Peripheral T-Cell Lymphoma (Angioimmunoblastic T-Cell Lymphoma) with a Human Monoclonal Antibody Against the CD4 Antigen (HuMax-CD4)
| Autor: | M. Pettersson, Gunilla Enblad, Hans Hagberg, T. Bjerner |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Angioimmunoblastic T-cell lymphoma Pathology medicine.drug_class Monoclonal antibody Internal medicine medicine Humans Aged Hematology biology business.industry Antibodies Monoclonal Lymphoma T-Cell Peripheral General Medicine medicine.disease Combined Modality Therapy Peripheral T-cell lymphoma Lymphoma Oncology Immunoblastic Lymphadenopathy CD4 Antigens Monoclonal biology.protein Immunotherapy Lymph Nodes Lymph Neoplasm Recurrence Local Antibody business |
| Zdroj: | Medical Oncology. 22:191-194 |
| ISSN: | 1357-0560 |
| DOI: | 10.1385/mo:22:2:191 |
| Popis: | A patient with a CD4+ refractory peripheral T-cell lymphoma (PTL), subtype angioimmunoblastic T-cell lymphoma (AILD), was treated with a human monoclonal anti-CD4 antibody (HuMax-CD4) iv once weekly for 10 wk. Early during treatment all palpable enlarged lymph nodes disappeared. A decline of normal CD4+ T-cells in the blood mirrored the treatment effect. Shortly after stopping treatment the patient relapsed with new enlarged lymph nodes. This time no antitumor effect was seen when HuMax-CD4 treatment was reinstituted. No severe side effects were observed during the antibody treatment. This case report is the first describing that HuMax-CD4 has antilymphoma activity in PTL and is an interesting drug to study further in patients with CD4+ PTL. |
| Databáze: | OpenAIRE |
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