Genetic characterization of multifocal tumor growth in renal cell carcinoma
| Autor: | Joerg Schubert, A. Schlichter, Kerstin Junker, Winfried Hindermann |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Pathology
medicine.medical_specialty Biology Malignancy urologic and male genital diseases lesion renal rumor Renal cell carcinoma Carcinoma medicine Humans Carcinoma Renal Cell Chromosome Aberrations Kidney Nucleic Acid Hybridization kidney cancer medicine.disease primary carcinoma Kidney Neoplasms Chromosome Banding Gene Expression Regulation Neoplastic medicine.anatomical_structure Tumor progression Nephrology Karyotyping Kidney cancer Comparative genomic hybridization Kidney disease |
| Zdroj: | Kidney International. 56(4):1291-1294 |
| ISSN: | 0085-2538 |
| DOI: | 10.1046/j.1523-1755.1999.00702.x |
| Popis: | Genetic characterization of multifocal tumor growth in renal cell carcinoma. The primary cancer found in the kidney is renal cell carcinoma (RCC), which does not as yet have a delineation of the types of lesions that progress to tumor malignancy. We studied tissues from primary tumors and secondary lesions, and compared it with the surrounding normal kidney tissue using comparative genomic hybridization to determine their potential for malignancy. Although our sample size was small, we found that small multifocal tumors have the same potential as primary carcinoma to lead to RCC malignancy. Further genetic studies in a larger sample of patients is necessary before the risk of different lesions to remain benign or progress to RCC can be defined absolutely. |
| Databáze: | OpenAIRE |
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