Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii
| Autor: | Sirichai Wangcharoentrakul, Patoomratana Tuchinda, Vichai Reutrakul, J. M. Graves, Lisa A. Shamon, John M. Pezzuto, Rajeshwari R. Mehta, Per Cleason, Ranee Sangsuwan, Suttiporn Chaichana |
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| Rok vydání: | 1997 |
| Předmět: |
Salmonella typhimurium
Cancer Research Ratón Mice Nude Pharmacology Celastraceae Mice chemistry.chemical_compound Animals Humans Cytotoxic T cell Cytotoxicity Antineoplastic Agents Alkylating Mice Inbred BALB C biology Mutagenicity Tests Mammary Neoplasms Experimental Biological activity Phenanthrenes Triptolide biology.organism_classification Oncology chemistry Epoxy Compounds Female Tripterygium wilfordii Diterpenes Drug Screening Assays Antitumor Diterpene |
| Zdroj: | Cancer Letters. 112:113-117 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/s0304-3835(96)04554-5 |
| Popis: | Triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii Hook f. (Celastraceae), has been shown to demonstrate potent antileukemic activity in rodent models at remarkably low treatment doses. A variety of other physiological responses are known to be mediated by this compound, including immunosuppressive and antifertility effects. We currently report that triptolide was not mutagenic toward Salmonella typhimurium strain TM677, either in the presence or absence of a metabolic activating system. Relatively potent but non-specific cytotoxicity was observed with a panel of cultured mammalian cell lines, and modest antitumor activity was observed when an i.p. dose of 25 microg was administered three times weekly to athymic mice carrying human breast tumors. Treatment regimens involving higher doses of triptolide (e.g. 50 microg/mouse three times weekly) were lethal. |
| Databáze: | OpenAIRE |
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