Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ob mice
| Autor: | Liu Lin Thio, Ebru Erbayat-Altay, Kelvin A. Yamada, Michael Wong |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Leptin
medicine.medical_specialty medicine.medical_treatment Adipokine Mice Obese Severity of Illness Index Epilepsy Mice Seizures Internal medicine medicine Reaction Time Animals Pentylenetetrazol Mice Knockout Analysis of Variance Leptin Deficiency Dose-Response Relationship Drug business.industry General Neuroscience digestive oral and skin physiology Electroencephalography medicine.disease nervous system diseases Mice Inbred C57BL Absence seizure Endocrinology Anticonvulsant Pentylenetetrazole business hormones hormone substitutes and hormone antagonists medicine.drug Ketogenic diet |
| Zdroj: | Neuroscience letters. 433(2) |
| ISSN: | 0304-3940 |
| Popis: | Leptin modulates multiple ion channels making its net effect on brain excitability difficult to predict. One method of determining leptin's net effect on brain excitability is to examine brain excitability during chronic leptin deficiency. We compared the susceptibility of leptin deficient ob/ob and wild type mice to pentylenetetrazol (PTZ) induced seizures using continuous video electroencephalogram (EEG) recordings. We found that ob/ob mice were more likely to die and were more susceptible to generalized clonic and clonic-tonic seizures than wild type mice at submaximal PTZ doses. These findings suggest that chronic leptin deficiency in vivo increases seizure susceptibility. |
| Databáze: | OpenAIRE |
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