Effects of platelet rich plasma on fascial healing in rats with fecal peritonitis
| Autor: | Ziya Çetinkaya, İbrahim Şeker, Yavuz Selim Ilhan, Refik Ayten, Kenan Binnetoğlu, Kazim Duman, Necip Ilhan, Burhan Hakan Kanat, Necati Timurkaan, Mustafa Girgin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Pathology RD1-811 medicine.medical_treatment Peritonitis Neovascularization Physiologic 030230 surgery Gastroenterology 03 medical and health sciences Hydroxyproline chemistry.chemical_compound Random Allocation 0302 clinical medicine Transforming Growth Factor beta Laparotomy Internal medicine Endopeptidases medicine Animals Fascia Rats Wistar Fibroblast Wound Healing business.industry Tumor Necrosis Factor-alpha Platelet-Rich Plasma Serine Endopeptidases Membrane Proteins Rats medicine.disease Cellular infiltration body regions medicine.anatomical_structure chemistry Gelatinases 030220 oncology & carcinogenesis Platelet-rich plasma Models Animal Surgery Collagen Wound healing business |
| Zdroj: | Acta Cirurgica Brasileira, Volume: 31, Issue: 5, Pages: 314-319, Published: MAY 2016 Acta Cirúrgica Brasileira v.31 n.5 2016 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Vol 31, Iss 5, Pp 314-319 (2016) |
| Popis: | PURPOSE : To evaluate the effects of platelet rich plasma (PRP) on the healing of fascia wherein peritonitis has been created. METHODS: Twenty eight Wistar Albino rats were divided into four groups. Only a primary fascial repair following laparotomy was performed on Group 1, a primary fascial repair performed and PRP treatment applied following laparotomy on Group 2, and a fecal peritonitis created following laparotomy and a primary fascial repair carried out on Group 3. A fecal peritonitis was created following laparotomy and primary fascial repair and PRP treatment on the fascia was carried out on Group 4. RESULTS: TNF-α was found to be significantly lower in the control group (Group 1). It was detected at the highest level in the group in which fecal peritonitis was created and PRP applied (Group 4). TGF-β was determined as being significantly higher only in Group 4. Histopathologically, the differences between the groups in terms of cell infiltration and collagen deposition were not found to be significant. CONCLUSION: When platelet rich plasma was given histologically and biochemicaly as wound healing parameters cellular infiltration, collagen accumulation, and tissue hydroxyiproline levels were not increased but neovascularization, fibroblast activation and TNF Alfa levels were increased and PRP accelerated wound healing. |
| Databáze: | OpenAIRE |
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