Antibodies to the axolemma-enriched fraction in the cerebrospinal fluid and serum of patients with multiple sclerosis and other neurological diseases
| Autor: | OA Khan, GH DeVries, VP Calabrese, JA Rawes |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Multiple Sclerosis Enzyme-Linked Immunosorbent Assay Immunoglobulin G 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Antigen medicine Humans 030212 general & internal medicine Aged Autoantibodies biology business.industry Multiple sclerosis Cell Membrane Autoantibody Middle Aged medicine.disease Axons Axolemma Neurology Immunology biology.protein Female Neurology (clinical) Nervous System Diseases Antibody business 030217 neurology & neurosurgery |
| Zdroj: | Multiple Sclerosis Journal. 3:363-369 |
| ISSN: | 1477-0970 1352-4585 |
| Popis: | Antibodies to an axolemma-enriched fraction (AEF) antigen have been detected in the cerebrospinal fluid (CSF) and serum of patients with Multiple Sclerosis (MS) using an enzyme-linked immunosorbent assay (ELISA). A marginal elevation (P < 0.08) of anti-AEF lgG was found in MS CSF when compared with OND samples. When CSF was diluted to a standardized lgG concentration, the anti-AEF lgG level in MS CSF was significantly elevated (P=0.007) when compared to OND CSF. MS serum was also found to contain a significantly higher level (P < 0.00 I ) of anti-AEF lgG when compared to OND serum using the ELISA technique. |
| Databáze: | OpenAIRE |
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