Präder-Willi syndrome fails to alter cardiac autonomic modulation
| Autor: | M Angulo, James S. Lieberman, John A. Downey, R. E. De Meersman, C K Wade |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Supine position Neurology medicine.medical_treatment Posture Blood Pressure Baroreflex Sitting Autonomic Nervous System Electrocardiography Heart Rate Respiration medicine Valsalva maneuver Humans medicine.diagnostic_test Endocrine and Autonomic Systems business.industry Hemodynamics Heart Anesthesia cardiovascular system Female Neurology (clinical) Analysis of variance business Prader-Willi Syndrome |
| Zdroj: | Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 10(4) |
| ISSN: | 0959-9851 |
| Popis: | Twenty-six healthy subjects with a diagnosis of Prader-Willi syndrome were compared with 26 age-, gender-, and body mass index-matched controls for autonomic modulation and baroreflex sensitivity. Electrocardiograms, beat-to-beat finger blood pressures, and respiration were recorded for several minutes in the following sequence: (1) supine, (2) after transition from supine to standing, (3) sitting, (4) during a Valsalva maneuver, (5) while performing moderate exercise, and (6) during recovery from exercise while seated. All recordings were channeled and stored in a computer; analyses were carried out at a later date. Power spectral analysis (fast-Fourier transform) of heart period variability was used to assess cardiac autonomic modulation. The slope of the regression equation between heart period and blood pressure rise after the Valsalva maneuver was used as an index of baroreflex sensitivity. Analysis of variance failed to reveal significant differences in any of the autonomic and baroreflex sensitivity variables between the two groups. Because breathing patterns entrain autonomic modulation, we verified respiration and found no differences between the two groups. Therefore, findings in the current investigation indicate that cardiac autonomic modulation in patients with Prader-Willi syndrome does not differ from age and body mass index-matched subjects. |
| Databáze: | OpenAIRE |
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