Effects of anticipated neonatal surgical intervention on maternal milk cytokine production
| Autor: | Jennifer L. Liedel, Melissa Christensen, Rebecca M. Rentea, Amy J. Wagner, David M. Gourlay |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Cytokine profile medicine.medical_treatment Mothers Breast milk Interleukin-23 Significant elevation 03 medical and health sciences 0302 clinical medicine medicine Humans Intensive care medicine Milk Human Obstetrics business.industry Infant Newborn General Medicine Evidence-based medicine Anticipation Psychological medicine.disease Interleukin-10 Expressed breast milk Cardiac surgery 030104 developmental biology Cytokine Surgical Procedures Operative Pediatrics Perinatology and Child Health Necrotizing enterocolitis Female Surgery business Stress Psychological 030215 immunology |
| Zdroj: | Journal of Pediatric Surgery. 52:45-49 |
| ISSN: | 0022-3468 |
| DOI: | 10.1016/j.jpedsurg.2016.10.017 |
| Popis: | Background Maternal stress on neonatal outcomes of infants admitted to the NICU is incompletely understood. We previously demonstrated breast milk derived cytokines remain biologically active in the neonatal intestine. We hypothesized that the need for neonatal surgical intervention would be stimulus leading to maternal cytokine production thus affecting neonatal outcome. Methods Discarded expressed breast milk (EBM) in the first 3weeks following delivery was analyzed for IL-23 and IL-10 by ELISA. Variables analyzed included: the need for a pediatric surgical procedure, the need for cardiac surgical procedure, no surgical interventions, and survival. All values are expressed as mean±SEM. Statistical analysis utilized Kruskal and Mann–Whitney test. Results EBM from mothers whose infants required any surgical procedure ( n =19) revealed significant elevation in IL-10 but not IL-23 compared to nonsurgical EBM ( n =18). Subdivided by procedure type, there was no difference between those undergoing a cardiac ( n =9) versus pediatric surgical ( n =10) procedure in both IL-10 and IL-23. Mothers whose infants requiring surgical intervention or whose infants did not survive in the first 3weeks of life had elevation of IL-10. Conclusion Results suggest maternal stress impacts the cytokine profile of breast milk. Level of evidence Level III. |
| Databáze: | OpenAIRE |
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