The persisting puzzle of racial disparity in triple negative breast cancer looking through a new lens
| Autor: | Bikram Sahoo, Shriya Joshi, Chakravarthy Garlapati, Shobhna Kapoor, Ritu Aneja |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Receptor ErbB-2 Triple Negative Breast Neoplasms Disease White People General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Breast cancer Tumor Microenvironment medicine Humans Gene Survival rate Triple-negative breast cancer Tumor microenvironment General Immunology and Microbiology business.industry Gene Expression Profiling Health Status Disparities Prognosis medicine.disease Phenotype Black or African American Gene expression profiling 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Female Receptors Progesterone business |
| Zdroj: | Frontiers in Bioscience. 11:75-88 |
| ISSN: | 1945-0524 1945-0516 |
| DOI: | 10.2741/s527 |
| Popis: | Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen and progesterone receptors and absence of amplification of human epidermal growth factor receptor (HER2). This disease has no approved treatment with a poor prognosis particularly in African-American (AA) as compared to European-American (EA) patients. Gene ontology analysis showed specific gene pathways that are differentially regulated and gene signatures that are differentially expressed in AA as compared to EA. Such differences might underlie the basis for the aggressive nature and poor prognosis of TNBC in AA patients. In-depth studies of these pathways and differential genetic signature might give significant clues to improve our understanding of tumor biology associated with AA TNBC to advance the prognosis and survival rates. Along with gene ontology analysis, we suggest that post-translational modifications (PTM) could also play a crucial role in the dismal survival rate of AA TNBC patients. Further investigations are necessary to explore this terrain of PTMs to identify the racially disparate burden in TNBC. |
| Databáze: | OpenAIRE |
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