Behavioral Signs of Chronic Back Pain in the SPARC-Null Mouse
| Autor: | Maral Tajerian, Imagali Millecamps, E. Helene Sage, Laura S. Stone |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pathology medicine.medical_specialty Hot Temperature Mice 129 Strain Cyclohexanecarboxylic Acids Gabapentin Anti-Inflammatory Agents Intervertebral Disc Degeneration Motor Activity Article Dexamethasone Degenerative disc disease Mice medicine Back pain Animals Humans Osteonectin Orthopedics and Sports Medicine Amines gamma-Aminobutyric Acid Mice Knockout Analgesics Referred pain Behavior Animal Morphine business.industry Age Factors Chronic pain medicine.disease Low back pain Cold Temperature Mice Inbred C57BL Hyperalgesia Radicular pain Anesthesia Chronic Disease Female Stress Mechanical Neurology (clinical) medicine.symptom business Low Back Pain medicine.drug |
| Zdroj: | Spine. 36:95-102 |
| ISSN: | 0362-2436 |
| Popis: | Study design Secreted Protein, Acidic, and Rich in Cysteine (SPARC)-null mice were examined for behavioral signs of chronic low back and/or radicular pain. Objective to assess SPARC-null mice as an animal model of chronic low back and/or radicular pain caused by degenerative disc disease. Summary of background data degeneration of intervertebral discs is a major cause of chronic low back and adicular pain in humans. Inactivation of the SPARC gene in mice results in premature intervertebral disc degeneration. The effect of disc degeneration on behavioral measures of chronic pain has not been evaluated in this model. Methods cohorts of young and old (3 and 6-12 months, respectively) SPARC-null and wild-type control mice were screened for behavioral indices of low back and/or radiating pain. Sensitivity to mechanical, cold and heat stimuli, locomotor impairment, and movement-evoked hypersensitivity were determined. Animals were challenged with 3 analgesic agents with different mechanisms: morphine, dexamethasone, and gabapentin. Results SPARC-null mice showed signs of movement-evoked discomfort as early as 3 months of age. Hypersensitivity to cold stimuli on both the lower back and hindpaws developed with increasing age. SPARC-null mice had normal sensitivity to tactile and heat stimuli, and locomotor skills were not impaired. The hypersensitivity to cold was reversed by morphine, but not by dexamethasone or gabapentin. Conclusion SPARC-null mice display behavioral signs consistent with chronic low back and radicular pain that we attribute to intervertebral disc degeneration. We hypothesize that the SPARC-null mouse is useful as a model of chronic back pain due to degenerative disc disease. |
| Databáze: | OpenAIRE |
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