Description and evaluation of a peracetic acid air sampling and analysis method
Autor: | Nathan Pechacek, John Nordling, Magdalena Osorio, Owen Kinsky |
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Rok vydání: | 2017 |
Předmět: |
Air sampling
Health Toxicology and Mutagenesis Air Pollutants Occupational Toxicology 01 natural sciences High-performance liquid chromatography 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Limit of Detection Peracetic acid Peracetic Acid Hydrogen peroxide Chromatography High Pressure Liquid Analysis method Refining (metallurgy) Detection limit Chromatography 010401 analytical chemistry Public Health Environmental and Occupational Health Parts-per notation biochemical phenomena metabolism and nutrition 030210 environmental & occupational health 0104 chemical sciences chemistry Environmental Monitoring |
Zdroj: | Toxicology and Industrial Health. 33:922-929 |
ISSN: | 1477-0393 0748-2337 |
DOI: | 10.1177/0748233717739165 |
Popis: | Peracetic acid (PAA) is a corrosive chemical with a pungent odor, which is extensively used in occupational settings and causes various health hazards in exposed workers. Currently, there is no US government agency recommended method that could be applied universally for the sampling and analysis of PAA. Legacy methods for determining airborne PAA vapor levels frequently suffered from cross-reactivity with other chemicals, particularly hydrogen peroxide (H2O2). Therefore, to remove the confounding factor of cross-reactivity, a new viable, sensitive method was developed for assessment of PAA exposure levels, based on the differential reaction kinetics of PAA with methyl p-tolylsulfide (MTS), relative to H2O2, to preferentially derive methyl p-tolysulfoxide (MTSO). By quantifying MTSO concentration produced in the liquid capture solution from an air sampler, using an internal standard, and utilizing the reaction stoichiometry of PAA and MTS, the original airborne concentration of PAA is determined. After refining this liquid trap high-performance liquid chromatography (HPLC) method in the laboratory, it was tested in five workplace settings where PAA products were used. PAA levels ranged from the detection limit of 0.013 parts per million (ppm) to 0.4 ppm. The results indicate a viable and potentially dependable method to assess the concentrations of PAA vapors under occupational exposure scenarios, though only a small number of field measurements were taken while field testing this method. However, the low limit of detection and precision offered by this method makes it a strong candidate for further testing and validation to expand the uses of this liquid trap HPLC method. |
Databáze: | OpenAIRE |
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