Deciphering Pleiotropic Signatures of Regulatory SNPs in Zea mays L. Using Multi-Omics Data and Machine Learning Algorithms
| Autor: | Armin Schmitt, Selina Wilhelmi, Mehmet Gültas, Ataul Haleem |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Inorganic Chemistry
Organic Chemistry General Medicine Physical and Theoretical Chemistry multi-omics regulatory SNPs incremental feature selection random forest markov clustering hierarchical network model gene expression profiles Molecular Biology Spectroscopy Catalysis Computer Science Applications |
| Zdroj: | International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 5121 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms23095121 |
| Popis: | Maize is one of the most widely grown cereals in the world. However, to address the challenges in maize breeding arising from climatic anomalies, there is a need for developing novel strategies to harness the power of multi-omics technologies. In this regard, pleiotropy is an important genetic phenomenon that can be utilized to simultaneously enhance multiple agronomic phenotypes in maize. In addition to pleiotropy, another aspect is the consideration of the regulatory SNPs (rSNPs) that are likely to have causal effects in phenotypic development. By incorporating both aspects in our study, we performed a systematic analysis based on multi-omics data to reveal the novel pleiotropic signatures of rSNPs in a global maize population. For this purpose, we first applied Random Forests and then Markov clustering algorithms to decipher the pleiotropic signatures of rSNPs, based on which hierarchical network models are constructed to elucidate the complex interplay among transcription factors, rSNPs, and phenotypes. The results obtained in our study could help to understand the genetic programs orchestrating multiple phenotypes and thus could provide novel breeding targets for the simultaneous improvement of several agronomic traits. |
| Databáze: | OpenAIRE |
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