Pro-inflammatory adipokine profile in psoriatic arthritis: results from a cross-sectional study comparing PsA subset with evident cutaneous involvement and subset 'sine psoriasis'

Autor: Marco Tasso, Bianca Covelli, Loredana Postiglione, Leonardo Punzi, Luisa Costa, Antonio Del Puente, Raffaele Scarpa, Nicolò Girolimetto, Francesco Caso, Vittoria D'Esposito, Luca Navarini, Domenico Paolo Emanuele Margiotta, Antonella Afeltra, Gaetano Di Spigna, Pietro Formisano, Rosario Peluso, Francesca Oliviero, Massimo Ciccozzi, Margherita Ricciardone
Přispěvatelé: Caso, F., Postiglione, L., Covelli, B., Ricciardone, Margherita, Di Spigna, G., Formisano, P., D'Esposito, V., Girolimetto, N., Tasso, M., Peluso, R., Navarini, L., Ciccozzi, M., Margiotta, D. P. E., Oliviero, F., Afeltra, A., Punzi, L., Del Puente, A., Scarpa, R., Costa, L.
Rok vydání: 2019
Předmět:
Zdroj: Clinical rheumatology (Print.) 38 (2019): 2547–2552. doi:10.1007/s10067-019-04619-w
info:cnr-pdr/source/autori:Caso F.; Postiglione L.; Covelli B.; Ricciardone M.; Di Spigna G.; Formisano P.; D'Esposito V.; Girolimetto N.; Tasso M.; Peluso R.; Navarini L.; Ciccozzi M.; Margiotta D.P.E.; Oliviero F.; Afeltra A.; Punzi L.; Del Puente A.; Scarpa R.; Costa L./titolo:Pro-inflammatory adipokine profile in psoriatic arthritis: results from a cross-sectional study comparing PsA subset with evident cutaneous involvement and subset "sine psoriasis"/doi:10.1007%2Fs10067-019-04619-w/rivista:Clinical rheumatology (Print.)/anno:2019/pagina_da:2547/pagina_a:2552/intervallo_pagine:2547–2552/volume:38
ISSN: 1434-9949
0770-3198
Popis: Objective: Adipokines have been considered in the pathogenesis of the inflammatory processes of psoriatic arthritis (PsA). The main aim of the current study is to investigate possible differences and correlations between adipokines and clinical expression in PsA patients with and without clinical evident psoriasis. Methods: Serum levels of TNF-?, IL-6, leptin, resistin, visfatin, and ghrelin were measured in 80 consecutive PsA patients, 42 PsA patients with clinically evident psoriasis (group 1) and 38 PsA patients sine psoriasis (group 2), fulfilling the CASPAR criteria. Results: Patients of the two groups were not significantly different for levels of TNF-?, IL-6, leptin, resistin, visfatin, and ghrelin. In the entire cohort, a positive association has been shown between leptin levels and female gender (? = 0.3, p = 0.001), BMI (? = 0.8, p < 0.0001), tender joint count (? = 0.23, p = 0.05), and patient pain-VAS score (? = 0.4, p = 0.049). In group 1, serum concentration of leptin was associated with female gender (? = 0.41, p < 0.0001) and BMI (? = 0.6, p = 0.012), whereas in group 2, a positive association was shown between leptin levels and BMI (? = 0.7, p = 0.003) and CRP (? = 0.35, p = 0.012). With regard to resistin, in the multivariate model, only the association between resistin and IL-6 was found (? = 0.33, p = 0.002). The association between resistin and IL-6 was confirmed in group 1 (? = 0.46, p = 0.004) but not in group 2. Conclusions: Until today, the present study represents the first investigating difference in the adipokine pattern between PsA patients with psoriasis and sine psoriasis. We report a strict interplay between leptin, female gender, BMI, and inflammatory activity in overall PsA patients. In PsA patients with clinical evident psoriasis, leptin was associated with female gender and BMI, and a close association between resistin and IL-6 was found. Further, a positive association between leptin levels and BMI and CRP was found in PsA sine psoriasis patients. Further studies are also advocated for clarifying the possible role of these adipokines as laboratory findings or as disease mediators in addressing the different phenotypes of the disease.Key PointsoLevels of TNF-?, IL-6, leptin, resistin, visfatin, and ghrelin did not differ between PsA patients with clinical evident psoriasis and PsA sine psoriasis.oThere is a strict interplay between leptin, female gender, BMI, and inflammatory activity in PsA.oThere is a close association between resistin and IL-6 in PsA patients with clinical evident psoriasis.
Databáze: OpenAIRE
Externí odkaz: