Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders

Autor: Ivana Kawikova, Sema Bilgic Gazioglu, Osman Abali, Abdurrahman Yildirim, Günnur Deniz, Selin Aktan Guloksuz, James F. Leckman, Sinan Guloksuz, Esin Aktas Cetin
Přispěvatelé: Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health
Rok vydání: 2015
Předmět:
0301 basic medicine
Male
Autism Spectrum Disorder
glia
medicine.medical_treatment
Autism
NF-KAPPA-B
Severity of Illness Index
S100B
Body Mass Index
0302 clinical medicine
lcsh:Psychiatry
cytokine
Child
2. Zero hunger
PSYCHIATRIC-DISORDERS
Interleukin
3. Good health
Psychiatry and Mental health
Cytokine
Autism spectrum disorder
Child
Preschool
Childhood Autism Rating Scale
Tumor necrosis factor alpha
Female
Original Article
Psychology
EXPRESSION
lcsh:RC435-571
tumor necrosis factor
INNATE
S100 Calcium Binding Protein beta Subunit
Proinflammatory cytokine
03 medical and health sciences
REGRESSION
mental disorders
medicine
Humans
Tumor Necrosis Factor-alpha
Interleukins
medicine.disease
MICROGLIAL ACTIVATION
030104 developmental biology
Cross-Sectional Studies
inflammation
Immunology
Body mass index
030217 neurology & neurosurgery
SYSTEM
Biomarkers
RESPONSES
Zdroj: Brazilian Journal of Psychiatry
Revista Brasileira de Psiquiatria, 39(3), 195-200. Associacao Brasileira de Psiquiatria
Brazilian Journal of Psychiatry, Iss 0
Brazilian Journal of Psychiatry v.39 n.3 2017
Brazilian Journal of Psychiatry (São Paulo. 1999. Online)
Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
Revista Brasileira de Psiquiatria, Volume: 39, Issue: 3, Pages: 195-200, Published: 12 JAN 2017
ISSN: 1809-452X
1516-4446
Popis: Objective: To investigate plasma concentrations of S100B (a calcium-binding protein derived primarily from the glia) and inflammatory cytokines in children with autism and the relationship between S100B and cytokine concentrations.Methods: Plasma levels of S100B, tumor necrosis factor alpha (TNF-alpha), interferon gamma, interleukin (IL)-1 beta, IL-4, IL-6, IL-10, and IL-17A were measured in 40 unmedicated children with autism and 35 normally developing healthy children. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS).Results: Concentrations of both S100B and TNF-alpha were higher in children with autism before and after adjusting for a priori-selected confounders (age, sex, and body mass index). S100B concentrations were higher in children with severe autism compared to children with mild-moderate autism. However, this association remained as a trend after adjusting for confounders. S100B concentrations correlated positively with TNF-alpha concentrations.Conclusion: Our findings showing an increase in peripheral concentrations of S100B and TNF-alpha provide limited support to the hypothesis about the roles of altered immune function and S100B in autism spectrum disorder (ASD). Studies of larger numbers of well-characterized individuals with ASD are needed to clarify the potential role of the immune system in the pathophysiology of this disorder.
Databáze: OpenAIRE
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