Effect of combined treatment with sub-Tenon injection of triamcinolone acetonide and photodynamic therapy in Japanese patients with age-related macular degeneration
| Autor: | Ryo Kawasaki, D. Tsuchiya, Shion Haneda, Teiko Yamamoto, Koko Saito, Hidetoshi Yamashita |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Triamcinolone acetonide genetic structures medicine.medical_treatment Mortise and tenon Visual Acuity Photodynamic therapy Risk Assessment Triamcinolone Acetonide Injections Macular Degeneration Combined treatment Asian People Japan Age related medicine Humans Glucocorticoids Aged Retrospective Studies business.industry General Medicine Macular degeneration medicine.disease Combined Modality Therapy Dermatology eye diseases Ophthalmology Treatment Outcome Photochemotherapy Connective Tissue Retreatment Female sense organs business Follow-Up Studies medicine.drug |
| Zdroj: | Japanese Journal of Ophthalmology. 53:512-518 |
| ISSN: | 1613-2246 0021-5155 |
| DOI: | 10.1007/s10384-009-0703-6 |
| Popis: | To evaluate the benefit of the combination of a single sub-Tenon injection of triamcinolone acetonide (STTA) with photodynamic therapy (PDT) for the treatment of age-related macular degeneration (AMD) in Japanese patients.The medical records of 111 eyes of 111 patients were reviewed retrospectively. Forty-five eyes underwent combined treatment with STTA and PDT, and 66 eyes underwent PDT alone. Time to vision loss, defined as a change of 0.3 or more logarithm of minimum angle of resolution (logMAR) units, and time to retreatment were evaluated using the Kaplan-Meier survival analyses. Cox regression models were used to estimate the hazard ratios for those end points to investigate clinical risk characteristics.Patients who underwent combined STTA with PDT had a significantly lower risk of retreatment than did those who underwent PDT alone (hazard ratio, 0.59; 95% confidence interval, 0.36-0.99). This beneficial association was found only in patients without polypoidal choroidal vasculopathy (PCV) lesions. However, combined treatment with STTA and PDT had no beneficial effect in reducing visual loss when compared with treatment with PDT alone.Combined treatment with STTA and PDT had a beneficial effect in reducing retreatment of AMD in Japanese patients. Those who had PCV lesions did not benefit from this additional treatment. |
| Databáze: | OpenAIRE |
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