Treatment of MRI-Diagnosed Trigeminal Peripheral Nerve Sheath Tumors by Stereotactic Radiotherapy in Dogs

Autor: Michael S. Kent, Alain P Theon, Allison L. Zwingenberger, Katherine S. Hansen, I. Pfeiffer
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
medicine.medical_treatment
Standard Article
Medical Records
0403 veterinary science
Stereotaxic Techniques
0302 clinical medicine
Stereotactic radiotherapy
Medicine
Dog Diseases
Cancer
Radiation
medicine.diagnostic_test
Medical record
04 agricultural and veterinary sciences
Trigeminal
Magnetic Resonance Imaging
Standard Articles
6.5 Radiotherapy and other non-invasive therapies
Veterinary
Treatment Outcome
Neurology
Trigeminal Nerve Diseases
030220 oncology & carcinogenesis
Female
Radiology
Neurilemmoma
medicine.drug
medicine.medical_specialty
040301 veterinary sciences
Disease-Free Survival
03 medical and health sciences
Dogs
Animals
Veterinary Sciences
Adverse effect
Stereotactic radiosurgery
Retrospective Studies
Trigeminal nerve
General Veterinary
business.industry
Neurosciences
Evaluation of treatments and therapeutic interventions
Retrospective cohort study
Magnetic resonance imaging
Surgery
6.5 Radiotherapy
Radiation therapy
Tumor progression
Anesthetic
SMALL ANIMAL
business
human activities
Zdroj: Hansen, KS; Zwingenberger, AL; Théon, AP; Pfeiffer, I; & Kent, MS. (2016). Treatment of MRI-Diagnosed Trigeminal Peripheral Nerve Sheath Tumors by Stereotactic Radiotherapy in Dogs. Journal of veterinary internal medicine, 30(4), 1112-1120. doi: 10.1111/jvim.13970. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/1k1769qp
Journal of veterinary internal medicine, vol 30, iss 4
Journal of Veterinary Internal Medicine
Popis: Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. BACKGROUND: Stereotactic radiotherapy (SRT) is an emerging technique for treating tumors in animals.OBJECTIVES: To assess the outcome of dogs with suspected intracranial trigeminal nerve peripheral nerve sheath tumors (PNST) treated with SRT.ANIMALS: Eight dogs with presumptive PNST.METHODS: This was a retrospective study of dogs identified by searching UC Davis Veterinary Medical Teaching Hospital medical records for dogs treated with SRT for a presumed PNST. Presumptive diagnosis was based on magnetic resonance imaging. SRT was delivered in 3 dose fractions of 8 Gray (Gy) on consecutive days or every other day to a total dose of 24 Gy.RESULTS: Median disease-specific survival was 745 days (range: 99-1375 days, n = 6). No signs of acute adverse effects of radiation treatment were recorded. Late radiation effects versus tumor progression could not be confirmed histopathologically because of few animals undergoing necropsy.CONCLUSIONS AND CLINICAL IMPORTANCE: This study provides preliminary evidence that dogs with PNST benefit from SRT in terms of long-term survival. The treatment appears to be well tolerated and requires fewer anesthetic events for animals compared to full-course radiation.
Databáze: OpenAIRE
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