Maternal hypertensive disorders and neurodevelopmental disorders in offspring: a population-based cohort in two Nordic countries

Autor: Krisztina László, Jun Zhang, Mika Gissler, Yongfu Yu, Hui Wang, Fei Li, Jiong Li
Rok vydání: 2020
Předmět:
Gestational hypertension
Adult
Male
Pediatrics
medicine.medical_specialty
Epidemiology
Offspring
Pre-Eclampsia/epidemiology
Intellectual disability
Register-based research
Cohort Studies
Prenatal Exposure Delayed Effects/epidemiology
Pre-Eclampsia
Pregnancy
Risk Factors
mental disorders
medicine
Attention deficit hyperactivity disorder
Humans
Perinatal Epidemiology
Intellectual Disability/epidemiology
Attention Deficit Disorder with Hyperactivity/epidemiology
Sibling
Autism spectrum disorder
Hypertensive disorders during pregnancy
Sweden
business.industry
Hazard ratio
Infant
Newborn
Infant
Neurodevelopmental Disorders/epidemiology
Hypertension
Pregnancy-Induced
medicine.disease
Sweden/epidemiology
Attention-deficit/hyperactivity disorder
Attention Deficit Disorder with Hyperactivity
Neurodevelopmental Disorders
Child
Preschool
Prenatal Exposure Delayed Effects
Female
Hypertension
Pregnancy-Induced/epidemiology
business
Pre-eclampsia
Zdroj: European Journal of Epidemiology
Wang, H, László, K D, Gissler, M, Li, F, Zhang, J, Yu, Y & Li, J 2021, ' Maternal hypertensive disorders and neurodevelopmental disorders in offspring : a population-based cohort in two Nordic countries ', European Journal of Epidemiology, vol. 36, no. 5, pp. 519-530 . https://doi.org/10.1007/s10654-021-00756-2
ISSN: 1573-7284
DOI: 10.1007/s10654-021-00756-2
Popis: Maternal hypertensive disorders during pregnancy (HDP) have been associated with neuropsychiatric problems in offspring. We aim to investigate the associations between specific types of maternal HDP and offspring neurodevelopmental disorders and further examine whether the timing of onset and severity of HDP would affect these associations. The study population consisted of 4,489,044 live-born singletons in Denmark during 1978–2012 and Sweden during 1987–2010. Maternal HDP was categorized into chronic hypertension, gestational hypertension, and pre-eclampsia; pre-eclampsia was further stratified according to timing (early-onset, late-onset), or severity (moderate, severe) of the disease. Neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and intellectual disability (ID), were defined by ICD-coded register diagnosis. Cox regression was used to calculate hazard ratios (HR) while adjusting for potential confounders, and sibling analyses assessed the influence of unmeasured shared familial factors. Maternal HDP was associated with increased risks of ADHD (HR, 1.24; 95% confidence interval [CI], 1.20–1.28), ASD (1.29 [1.24–1.34]), and ID (1.58 [1.50–1.66]) in offspring, respectively, which was mostly driven by pre-eclampsia. The strongest associations were observed for early-onset and severe pre-eclampsia, and the corresponding HRs for ADHD, ASD and ID were 1.93 [1.73–2.16], 1.86 [1.61–2.15], and 3.99 [3.42–4.65], respectively. The results were similar in the sibling analyses. The associations between maternal HDP and offspring neurodevelopmental disorders were consistent across the subgroups of sex, preterm status, parity, maternal age and psychiatric disorders. Maternal HDP, especially early-onset pre-eclampsia, are associated with increased risks of ADHD, ASD, and ID in particular, independent of shared familial factors. Supplementary Information The online version contains supplementary material available at 10.1007/s10654-021-00756-2.
Databáze: OpenAIRE
Externí odkaz: