Subcutaneous infiltration with ammonium sulphate 10% does not prolong the local anaesthetic duration of lidocaine in humans
| Autor: | S. Møiniche, J. B. Dahl, A. Dahl |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pain Threshold Ammonium sulfate Hot Temperature Time Factors Lidocaine Visual analogue scale medicine.drug_class Injections Subcutaneous Stimulation chemistry.chemical_compound Physical Stimulation medicine Humans Ammonium Local anesthesia Anesthetics Local Local anesthetic business.industry General Medicine medicine.disease Anesthesiology and Pain Medicine chemistry Ammonium Sulfate Area Under Curve Anesthesia business Infiltration (medical) Adjuvants Anesthesia Anesthesia Local medicine.drug |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 44:878-883 |
| ISSN: | 1399-6576 0001-5172 |
| DOI: | 10.1034/j.1399-6576.2000.440716.x |
| Popis: | Background: The aim of the present study was to investigate whether a solution of ammonium sulphate and lidocaine had a prolonged duration of action compared with lidocaine alone after subcutaneous infiltration in human volunteers. Methods: In a double-blind, randomised, controlled trial 12 male volunteers had either 4 ml lidocaine 1% (40 mg) or a solution of 4 ml ammonium sulphate 10% and lidocaine 1% (40 mg) subcutaneously infiltrated in corresponding skin areas on the right and left calf. The duration of the local anaesthetic action of the test medications was assessed 1–6 h after the infiltrations using thresholds to mechanical (von Frey hairs) and thermal stimulation (heat detection thresholds: HDT, and heat pain dectection thresholds: HPDT), and by calculation of areas under the curve (AUC) for electronic visual analogue scale (VAS) pain ratings (sampled at 2 Hz) during a heat stimulation on the test areas for 30 s with a 45°C warm thermode. Results: At no assessment were thresholds to mechanical or thermal stimulation increased in favour of ammonium sulphate treated legs compared with control legs. On the contrary, HPDT were significantly lower in ammonium sulphate treated legs than control legs at the 3 h and 4 h assessment after infiltration (P |
| Databáze: | OpenAIRE |
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