Prevalence and complications of nonsurgical hypoparathyroidism in Korea: A nationwide cohort study
Autor: | Young Jun Won, Jung Hyun Noh, Sin Gon Kim, Se Hwa Kim, Yoo Mee Kim, Hyemi Moon, Yumie Rhee, Juneyoung Lee |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Bipolar Disorder Critical Care and Emergency Medicine Organic chemistry Comorbidity 030204 cardiovascular system & hematology Cardiovascular Medicine Cohort Studies Geographical Locations 0302 clinical medicine Prevalence Medicine and Health Sciences Medicine Vitamin D Depression (differential diagnoses) Trauma Medicine Metabolic Syndrome Multidisciplinary Hazard ratio Vitamins Middle Aged Physical sciences Chemistry Cardiovascular Diseases Bone Fracture Research Design Spinal Fractures Female Urinary Calculi Traumatic Injury Arrhythmia Cohort study Research Article Adult medicine.medical_specialty Asia Hypoparathyroidism Science Cardiology 030209 endocrinology & metabolism Research and Analysis Methods Cataract Autoimmune Diseases 03 medical and health sciences Young Adult Chemical compounds Seizures Internal medicine Republic of Korea Organic compounds Humans Propensity Score Heart Failure Depressive Disorder Korea business.industry Cataracts Case-control study Retrospective cohort study medicine.disease Confidence interval Ophthalmology Fractures Spontaneous Case-Control Studies Lens Disorders People and Places business |
Zdroj: | PLoS ONE, Vol 15, Iss 5, p e0232842 (2020) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Objective The risk of complications of nonsurgical hypoparathyroidism in Asia is unclear. We estimated the prevalence and risk of complications in patients with nonsurgical hypoparathyroidism. Methods We performed a retrospective cohort study using a nationwide claims database from 2005 to 2016. Among the entire Korean population, we identified 897 patients diagnosed with nonsurgical hypoparathyroidism during 2005-2015. We selected 210 patients with nonsurgical hypoparathyroidism during 2005-2008 who had no complications at baseline and followed them to 2016. Control subjects (n = 2075) were matched using propensity scores based on age, sex, and comorbid disease with a 1:10 ratio and monitored until 2016. Results The age-standardized prevalence of nonsurgical hypoparathyroidism was 0.2 cases per 100,000 persons in 2005. During a mean follow-up period of 9.5 years, patients with nonsurgical hypoparathyroidism had a higher risk of cardiovascular disease, especially arrhythmia (hazard ratio [HR], 2.03; 95% confidence interval [CI], 1.11-3.70) and heart failure (HR, 2.43; 95% CI, 1.22-4.83). The risk of vertebral fracture was higher in patients than in controls (HR, 2.27; 95% CI, 1.09-4.72). Patients had a significantly increased risk of renal disease (HR, 2.57; 95% CI, 1.56-4.21), seizure (HR, 5.74; 95% CI, 3.34-9.86), depression and bipolar disease (HR, 1.82; 95% CI, 1.30-2.56), and cataract (HR, 1.90; 95% CI, 1.30-2.79) compared with controls. Conclusions The prevalence of nonsurgical hypoparathyroidism was very low in Korea but was associated with a higher risk of incident cardiovascular disease and vertebral fracture as well as known complications including renal disease, seizure, and cataract. |
Databáze: | OpenAIRE |
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