Prevalence and complications of nonsurgical hypoparathyroidism in Korea: A nationwide cohort study

Autor: Young Jun Won, Jung Hyun Noh, Sin Gon Kim, Se Hwa Kim, Yoo Mee Kim, Hyemi Moon, Yumie Rhee, Juneyoung Lee
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Bipolar Disorder
Critical Care and Emergency Medicine
Organic chemistry
Comorbidity
030204 cardiovascular system & hematology
Cardiovascular Medicine
Cohort Studies
Geographical Locations
0302 clinical medicine
Prevalence
Medicine and Health Sciences
Medicine
Vitamin D
Depression (differential diagnoses)
Trauma Medicine
Metabolic Syndrome
Multidisciplinary
Hazard ratio
Vitamins
Middle Aged
Physical sciences
Chemistry
Cardiovascular Diseases
Bone Fracture
Research Design
Spinal Fractures
Female
Urinary Calculi
Traumatic Injury
Arrhythmia
Cohort study
Research Article
Adult
medicine.medical_specialty
Asia
Hypoparathyroidism
Science
Cardiology
030209 endocrinology & metabolism
Research and Analysis Methods
Cataract
Autoimmune Diseases
03 medical and health sciences
Young Adult
Chemical compounds
Seizures
Internal medicine
Republic of Korea
Organic compounds
Humans
Propensity Score
Heart Failure
Depressive Disorder
Korea
business.industry
Cataracts
Case-control study
Retrospective cohort study
medicine.disease
Confidence interval
Ophthalmology
Fractures
Spontaneous
Case-Control Studies
Lens Disorders
People and Places
business
Zdroj: PLoS ONE, Vol 15, Iss 5, p e0232842 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: Objective The risk of complications of nonsurgical hypoparathyroidism in Asia is unclear. We estimated the prevalence and risk of complications in patients with nonsurgical hypoparathyroidism. Methods We performed a retrospective cohort study using a nationwide claims database from 2005 to 2016. Among the entire Korean population, we identified 897 patients diagnosed with nonsurgical hypoparathyroidism during 2005-2015. We selected 210 patients with nonsurgical hypoparathyroidism during 2005-2008 who had no complications at baseline and followed them to 2016. Control subjects (n = 2075) were matched using propensity scores based on age, sex, and comorbid disease with a 1:10 ratio and monitored until 2016. Results The age-standardized prevalence of nonsurgical hypoparathyroidism was 0.2 cases per 100,000 persons in 2005. During a mean follow-up period of 9.5 years, patients with nonsurgical hypoparathyroidism had a higher risk of cardiovascular disease, especially arrhythmia (hazard ratio [HR], 2.03; 95% confidence interval [CI], 1.11-3.70) and heart failure (HR, 2.43; 95% CI, 1.22-4.83). The risk of vertebral fracture was higher in patients than in controls (HR, 2.27; 95% CI, 1.09-4.72). Patients had a significantly increased risk of renal disease (HR, 2.57; 95% CI, 1.56-4.21), seizure (HR, 5.74; 95% CI, 3.34-9.86), depression and bipolar disease (HR, 1.82; 95% CI, 1.30-2.56), and cataract (HR, 1.90; 95% CI, 1.30-2.79) compared with controls. Conclusions The prevalence of nonsurgical hypoparathyroidism was very low in Korea but was associated with a higher risk of incident cardiovascular disease and vertebral fracture as well as known complications including renal disease, seizure, and cataract.
Databáze: OpenAIRE
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