Effect of in vivo plasma insulin levels on the relationship between perfusate free fatty acid concentration and triglyceride secretion by perfused rat livers
| Autor: | Mondon Ce, Reaven Gm |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Stimulation Fatty Acids Nonesterified Lipoproteins VLDL Biochemistry Diabetes Mellitus Experimental chemistry.chemical_compound Endocrinology In vivo Internal medicine medicine Animals Insulin Secretion Triglycerides chemistry.chemical_classification Triglyceride Biochemistry (medical) Hypertriglyceridemia Fatty acid Rats Inbred Strains General Medicine medicine.disease Rats Perfusion chemistry Liver Plasma insulin hormones hormone substitutes and hormone antagonists |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 16(5) |
| ISSN: | 0018-5043 |
| Popis: | Previous evidence has indicated that plasma concentrations of insulin and free fatty acid (FFA) play crucial roles in regulation of hepatic triglyceride (TG) secretion. To further define the relationship between these variables, we have assessed the effect of pre-existing ambient insulin levels on the ability of perfusate FFA concentrations to stimulate TG secretion by perfused livers from five groups of rats. The groups and their mean plasma in vivo insulin concentrations were as follows: sucrose-fed (49 microU/ml), control (35 microU/ml), moderate streptozotocin-induced insulin deficiency (24 microU/ml), semi-starved control (11 microU/ml), and severe streptozotocin-induced insulin deficiency (6 microU/ml). Hepatic TG secretion by perfused rat livers from all five groups was stimulated by increments in perfusate FFA concentration. However, the magnitude of the stimulation of hepatic TG secretion by any given perfusate FFA concentration varied considerably among the groups, and appeared to be directly related to the height of the in vivo insulin concentrations. These results indicate that TG secretion by perfused rat livers is related to perfusate FFA concentrations, but emphasize the importance that pre-existing ambient insulin levels have in modulating the quantitative nature of this relationship. |
| Databáze: | OpenAIRE |
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