Erectile dysfunction is more common in young to middle-aged HIV-infected men than in HIV-uninfected men
| Autor: | Kety Luzi, Chiara Stentarelli, Stefano Zona, Vincenzo Rochira, Daniele Santi, Mattia Beggi, Bruno Madeo, Giovanni Guaraldi |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Premature aging Gerontology medicine.medical_specialty erectile dysfunction Urology Endocrinology Diabetes and Metabolism Human immunodeficiency virus (HIV) Sexual dysfunction HIV Infections medicine.disease_cause Logistic regression Endocrinology Erectile Dysfunction Premature Aging Surveys and Questionnaires Internal medicine Prevalence medicine Humans business.industry Age Factors virus diseases HIV Anthropometry medicine.disease IIEF-15 Psychiatry and Mental health Cross-Sectional Studies Logistic Models Erectile dysfunction chronic disease Reproductive Medicine Case-Control Studies Observational study medicine.symptom business Body mass index |
| Popis: | Erectile dysfunction (ED) is common among elderly men and patients suffering from chronic diseases, the latter probably including also HIV infection. No studies, however, compared the prevalence of ED in HIV-infected and HIV-uninfected individuals using the international index of erectile function (IIEF-15).The aim of this study is to compare ED prevalence in young to middle-aged men with and without HIV infection using the IIEF-15 questionnaire.We conducted a cross-sectional, observational, controlled study on 444 HIV-infected men and 71 HIV-uninfected men.The IIEF-15 questionnaire was used to assess ED. A cutoff score of ≤25 of the erectile domain was used to diagnose ED. Serum testosterone, demographic, and anthropometric (weight, height, and body mass index [BMI]) characteristics were obtained from all participants. Statistics included the T-test, the Fisher's test, univariable and multivariable logistic regression, and univariate and multivariate Spearman's correlation analysis.The HIV-uninfected group was significantly younger than the HIV-infected group and presented a higher BMI (P 0.001). The prevalence of mild, moderate, and severe ED was higher in HIV-infected men than in HIV-uninfected men of all decades of age. In univariate analysis, HIV infection was associated with ED (odds ratio [OR] = 34.19, P 0.001). In multivariable logistic regression analysis, HIV infection remained the strongest predictors of ED (OR = 42.26, P 0.001) followed by hypogonadism, after adjusting for age and BMI.This study demonstrates a clear association between ED and HIV infection, after adjusting for age and BMI. Other than HIV infection, hypogonadism was associated with ED. In addition, the prevalence of ED was higher in HIV-infected men than in HIV-uninfected men, in all decades of age. The early onset of ED in HIV-infected men could be considered a peculiar clinical hallmark of HIV and confirms precocious aging in these patients. ED should be of concern to clinicians when managing HIV-infected men even if the latter are young or middle aged. |
| Databáze: | OpenAIRE |
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