Curcumin Ameliorates Memory Deficits by Enhancing Lactate Content and MCT2 Expression in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease
| Autor: | Si-Qin Huang, Yu Li, Guo-Ping Qiu, Fei Zhuo, Xu-Li Jiang, Jin Xu, Wei-Tian Lu, Shengwei Gan, Juan Huang, Shiye Xu, Shanquan Sun |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Genetically modified mouse Male Monocarboxylic Acid Transporters medicine.medical_specialty Histology Curcumin Hippocampus Mice Transgenic Neuroprotection 03 medical and health sciences chemistry.chemical_compound Amyloid beta-Protein Precursor Mice 0302 clinical medicine Alzheimer Disease Internal medicine mental disorders medicine Presenilin-1 Animals Lactic Acid Ecology Evolution Behavior and Systematics Monocarboxylate transporter Memory Disorders biology Long-term memory Anti-Inflammatory Agents Non-Steroidal Blot Mice Inbred C57BL Disease Models Animal 030104 developmental biology Endocrinology medicine.anatomical_structure nervous system chemistry Cerebral cortex biology.protein Female Anatomy 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | Anatomical record (Hoboken, N.J. : 2007). 302(2) |
| ISSN: | 1932-8494 |
| Popis: | Curcumin is a natural product with several anti-Alzheimer's disease (AD) neuroprotective properties. This study aimed to investigate the effects of curcumin on memory deficits, lactate content, and monocarboxylate transporter 2 (MCT2) in APP/PS1 mouse model of AD. APP/PS1 transgenic mice and wild-type (WT) C57BL/6J mice were used in the present study. Spatial learning and memory of the mice was detected using Morris water-maze test. Cerebral cortex and hippocampus lactate contents were detected using lactate assay. MCT2 expression in the cerebral cortex and hippocampus was examined by immunohistochemistry and Western blotting. Results showed that spatial learning and memory deficits were improved in curcumin-treated APP/PS1 mouse group compared with those in APP/PS1 mice group. Brain lactate content and MCT2 protein level were increased in curcumin-treated APP/PS1 mice than in APP/PS1 mice. In summary, our findings indicate that curcumin could ameliorate memory impairments in APP/PS1 mouse model of AD. This phenomenon may be at least partially due to its improving effect on the lactate content and MCT2 protein expression in the brain. Anat Rec, 302:332-338, 2019. © 2018 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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