Philadelphia chromosome positive blood B lymphocytes in chronic myelocytic leukemia
| Autor: | A. Bussel, S. Labaume, Alain Bernheim, Roland Berger, R. Barot-Ciorbaru, J.L. Preud'homme |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male Cancer Research Lymphocyte Fluorescent Antibody Technique Receptors Antigen B-Cell Stimulation Biology Philadelphia chromosome Immunofluorescence medicine Chromosomes Human 21-22 and Y Humans Mitosis B cell Aged Chromosome Aberrations B-Lymphocytes Philadelphia Chromosome Positive medicine.diagnostic_test Hematology Middle Aged medicine.disease Molecular biology Chromosome Banding medicine.anatomical_structure Oncology Immunoglobulin M Polyclonal antibodies Leukemia Myeloid Immunology biology.protein Female |
| Zdroj: | Leukemia research. 5(4-5) |
| ISSN: | 0145-2126 |
| Popis: | Philadelphia chromosome and surface IgM were studied at the individual cell level in blood lymphocytes from 18 patients with chronic myelocytic leukemia using an assay that combines surface immunofluorescence and Q-banding. After stimulation by polyclonal B cell activators, clear-cut results were obtained in eight cases, the technical failures in the other patients being predominantly due to the absence of B lymphocyte mitoses. The great majority of B cell mitoses that were analyzable in the chromosomal study contained the Ph 1 marker. |
| Databáze: | OpenAIRE |
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