Detection of histone acetylation levels in the dorsal hippocampus reveals early tagging on specific residues of H2B and H4 histones in response to learning
| Autor: | Jean-Christophe Cassel, Olivier Bousiges, Jean-Philippe Loeffler, Anne-Laurence Boutillier, Anne Schneider, Anne Pereira de Vasconcelos, Alexandra Barbelivien, Marc-Antoine Muller, Romain Neidl, Monique Majchrzak |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Gene Expression Hippocampus lcsh:Medicine Social and Behavioral Sciences Bioinformatics Biochemistry Histones Learning and Memory 0302 clinical medicine Molecular Cell Biology Psychology Fear conditioning Amino Acids lcsh:Science Regulation of gene expression 0303 health sciences Multidisciplinary biology Acetylation Histone Modification Fear Animal Models Chromatin Histone Epigenetics Research Article Epigenetics in learning and memory 03 medical and health sciences Model Organisms Memory Genetics Animals Rats Long-Evans Maze Learning Biology 030304 developmental biology lcsh:R Cognitive Psychology Animal Cognition Rats Gene Expression Regulation Space Perception biology.protein Rat lcsh:Q Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | PLoS ONE, Vol 8, Iss 3, p e57816 (2013) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | The recent literature provides evidence that epigenetic mechanisms such as DNA methylation and histone modification are crucial to gene transcription linked to synaptic plasticity in the mammalian brain - notably in the hippocampus - and memory formation. We measured global histone acetylation levels in the rat hippocampus at an early stage of spatial or fear memory formation. We found that H3, H4 and H2B underwent differential acetylation at specific sites depending on whether rats had been exposed to the context of a task without having to learn or had to learn about a place or fear therein: H3K9K14 acetylation was mostly responsive to any experimental conditions compared to naive animals, whereas H2B N-terminus and H4K12 acetylations were mostly associated with memory for either spatial or fear learning. Altogether, these data suggest that behavior/experience-dependent changes differently regulate specific acetylation modifications of histones in the hippocampus, depending on whether a memory trace is established or not: tagging of H3K9K14 could be associated with perception/processing of testing-related manipulations and context, thereby enhancing chromatin accessibility, while tagging of H2B N-terminus tail and H4K12 could be more closely associated with the formation of memories requiring an engagement of the hippocampus. |
| Databáze: | OpenAIRE |
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