Chromium-cage complex as contrast agent in MR imaging—Biodistribution studies of the [57Co]cobalt analogue
| Autor: | G. Blekkenhorst, Graham E. Jackson, Antony J. Hendry, Michael J. Byrne |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Biodistribution Contrast Media chemistry.chemical_element Kidney law.invention Mice Chromium Nuclear magnetic resonance Heterocyclic Compounds law Rhabdomyosarcoma Animals Tissue Distribution Tissue distribution Cobalt Radioisotopes Radionuclide Imaging Renal uptake Mice Inbred BALB C Radioactive tracer Radiochemistry Sarcosine Cobalt General Medicine Magnetic Resonance Imaging Mr imaging chemistry Cage Neoplasm Transplantation |
| Zdroj: | International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. 18:855-858 |
| ISSN: | 0883-2897 |
| DOI: | 10.1016/0883-2897(91)90093-z |
| Popis: | The synthesis and T1 and T2 relaxivities of the Cr(III)-(NH2)-Sar-cage complex is reported. An outer-sphere relaxation mechanism is postulated for the relaxivity of the complex. Tissue distribution studies in mice using a [57Co]cobalt analogue as a radioactive tracer showed that the complex is excreted rapidly in the urine. Some renal uptake of the complex is seen. Appreciable uptake of labelled cage complex was observed in 3-methylcholanthrene induced murine rhabdomyosarcoma. |
| Databáze: | OpenAIRE |
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