HBsAg clearance in chronic hepatitis B patients with add-on pegylated interferon alfa-2a to ongoing tenofovir treatment: A randomized controlled study

Autor: Einar Thoralsson, Musthafa Chalikandy Peedikayil, Ahmed Al Jedai, Mohammed Al Quaiz, Mohammed Q. Khan, Hamad Al Ashgar, Khalid Al Kahtani, Abdulrahman Al Fadda, Fahad Al Sohaibani, Sahar Al Thawadi
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
HBsAg
medicine.disease_cause
Gastroenterology
Chronic hepatitis B
Polyethylene Glycols
0302 clinical medicine
Pegylated interferon
immune system diseases
seroprevalence
virus diseases
clinical trial
Hepatitis B
Middle Aged
Viral Load
Recombinant Proteins
030211 gastroenterology & hepatology
Original Article
Drug Therapy
Combination
Female
Viral load
medicine.drug
Adult
medicine.medical_specialty
Injections
Subcutaneous
clearance
Antiviral Agents
03 medical and health sciences
Pharmacotherapy
Hepatitis B
Chronic
Internal medicine
medicine
Humans
Seroconversion
lcsh:RC799-869
Hepatitis B Antibodies
Tenofovir
Hepatitis B virus
Hepatitis B Surface Antigens
business.industry
Interferon-alpha
medicine.disease
digestive system diseases
Regimen
hepatitis B surface antigen
030104 developmental biology
Immunology
DNA
Viral
lcsh:Diseases of the digestive system. Gastroenterology
business
hepatitis B virus
Zdroj: Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
The Saudi Journal of Gastroenterology, Vol 23, Iss 3, Pp 190-198 (2017)
ISSN: 1998-4049
1319-3767
Popis: Background/Aims: The ideal end point of treatment for chronic hepatitis B virus (HBV) infection is sustained off-therapy hepatitis B surface antigen (HBsAg) loss with or even without seroconversion to anti-HBs. We investigated the role of adding PEGylated interferon (PEG IFN) to ongoing tenofovir treatment in chronic HBV patients for achieving HBsAg clearance. Patients and Methods: In this randomized controlled trial, chronic HBV patients who have been receiving tenofovir for >6 months with HBV viral load
Databáze: OpenAIRE
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