Recent Advances in Photodynamic Therapy against Fungal Keratitis
| Autor: | Chun Keung Yu, Chaw Ning Lee, Chi-Jung Wu, Yun Chang, Tak Wah Wong, Jia-Horung Hung, Huai-Wen Hsu, I-Son Ng, Nan Yao Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class medicine.medical_treatment Antibiotics Pharmaceutical Science Photodynamic therapy Drug resistance Review Keratitis rose bengal drug-resistance Pharmacy and materia medica Cornea medicine Fungal keratitis Corneal epithelium business.industry fungal infection medicine.disease Dermatology eye diseases flavin mononucleotide Clinical trial RS1-441 medicine.anatomical_structure keratitis photodynamic therapy drug delivery candida business collagen cross-linking |
| Zdroj: | Pharmaceutics, Vol 13, Iss 2011, p 2011 (2021) Pharmaceutics |
| ISSN: | 1999-4923 |
| Popis: | Fungal keratitis is a serious clinical infection on the cornea caused by fungi and is one of the leading causes of blindness in Asian countries. The treatment options are currently limited to a few antifungal agents. With the increasing incidence of drug-resistant infections, many patients fail to respond to antibiotics. Riboflavin-mediated corneal crosslinking (similar to photodynamic therapy (PDT)) for corneal ectasia was approved in the US in the early 2000s. Current evidence suggests that PDT could have the potential to inhibit fungal biofilm formation and overcome drug resistance by using riboflavin and rose bengal as photosensitizers. However, only a few clinical trials have been initiated in anti-fungal keratitis PDT treatment. Moreover, the removal of the corneal epithelium and repeated application of riboflavin and rose bengal are required to improve drug penetration before and during PDT. Thus, an improvement in trans-corneal drug delivery is mandatory for a successful and efficient treatment. In this article, we review the studies published to date using PDT against fungal keratitis and aim to enhance the understanding and awareness of this research area. The potential of modifying photosensitizers using nanotechnology to improve the efficacy of PDT on fungal keratitis is also briefly reviewed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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